Detailed information NTG1150073

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DXE57_RS05565
• Genome accession: NZ_LT992476
• Coordinates: 1074642..1075685 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 21_LA_436
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1069642..1080685

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE57_RS05530	-	1070256..1070366 (+)	111	WP_014937049.1	hypothetical protein	-
DXE57_RS05535	-	1070395..1070808 (+)	414	WP_025174370.1	hypothetical protein	-
DXE57_RS05540	-	1070997..1071983 (-)	987	WP_000999712.1	FUSC family protein	-
DXE57_RS05550	map	1072567..1073325 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DXE57_RS05555	-	1073542..1073928 (+)	387	WP_001110182.1	hypothetical protein	-
DXE57_RS05560	liaF	1073943..1074645 (+)	703	Protein_1060	cell wall-active antibiotics response protein LiaF	-
DXE57_RS05565	vraS	1074642..1075685 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DXE57_RS05570	vraR	1075675..1076304 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DXE57_RS05575	-	1076417..1077634 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DXE57_RS05580	-	1077912..1078187 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
DXE57_RS05585	-	1078194..1078658 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DXE57_RS05590	-	1078805..1079005 (+)	201	WP_000180460.1	DUF1128 family protein	-
DXE57_RS05595	-	1079008..1080264 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1150073 DXE57_RS05565 WP_001017131.1 1074642..1075685(+) (vraS) [Staphylococcus aureus isolate 21_LA_436]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1150073 DXE57_RS05565 WP_001017131.1 1074642..1075685(+) (vraS) [Staphylococcus aureus isolate 21_LA_436]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1