Detailed information NTG1150024

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DXE41_RS02480
• Genome accession: NZ_LT992475
• Coordinates: 435789..436832 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 20_LA_415
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 430789..441832

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE41_RS02445	-	431404..431514 (+)	111	WP_014937049.1	hypothetical protein	-
DXE41_RS02450	-	431543..431956 (+)	414	WP_025174370.1	hypothetical protein	-
DXE41_RS02455	-	432145..433131 (-)	987	WP_000999712.1	FUSC family protein	-
DXE41_RS02465	map	433715..434473 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DXE41_RS02470	-	434690..435076 (+)	387	WP_001110182.1	hypothetical protein	-
DXE41_RS02475	liaF	435091..435792 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DXE41_RS02480	vraS	435789..436832 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DXE41_RS02485	vraR	436822..437451 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DXE41_RS02490	-	437564..438781 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DXE41_RS02495	-	439059..439334 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
DXE41_RS02500	-	439341..439805 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DXE41_RS02505	-	439952..440152 (+)	201	WP_000180460.1	DUF1128 family protein	-
DXE41_RS02510	-	440155..441411 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1150024 DXE41_RS02480 WP_001017131.1 435789..436832(+) (vraS) [Staphylococcus aureus isolate 20_LA_415]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1150024 DXE41_RS02480 WP_001017131.1 435789..436832(+) (vraS) [Staphylococcus aureus isolate 20_LA_415]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1