Detailed information NTG1150013

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DXE66_RS13150
• Genome accession: NZ_LT992474
• Coordinates: 2579003..2580046 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 19_LA_388
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2574003..2585046

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE66_RS13120	-	2574424..2575680 (-)	1257	WP_074347694.1	aminopeptidase	-
DXE66_RS13125	-	2575683..2575883 (-)	201	WP_000180460.1	DUF1128 family protein	-
DXE66_RS13130	-	2576030..2576494 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DXE66_RS13135	-	2576501..2576776 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DXE66_RS13140	-	2577054..2578271 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DXE66_RS13145	vraR	2578384..2579013 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DXE66_RS13150	vraS	2579003..2580046 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DXE66_RS13155	liaF	2580043..2580744 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DXE66_RS13160	-	2580759..2581145 (-)	387	WP_001110182.1	hypothetical protein	-
DXE66_RS13165	map	2581362..2582120 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DXE66_RS13175	-	2582704..2583690 (+)	987	WP_000999712.1	FUSC family protein	-
DXE66_RS13180	-	2583879..2584292 (-)	414	WP_025174370.1	hypothetical protein	-
DXE66_RS13185	-	2584321..2584431 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1150013 DXE66_RS13150 WP_001017131.1 2579003..2580046(-) (vraS) [Staphylococcus aureus isolate 19_LA_388]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1150013 DXE66_RS13150 WP_001017131.1 2579003..2580046(-) (vraS) [Staphylococcus aureus isolate 19_LA_388]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1