Detailed information NTG1149881

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DXE46_RS10735
• Genome accession: NZ_LT992471
• Coordinates: 2081867..2082910 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 17_LA_343
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2076867..2087910

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE46_RS10705	-	2077288..2078544 (-)	1257	WP_074347694.1	aminopeptidase	-
DXE46_RS10710	-	2078547..2078747 (-)	201	WP_000180460.1	DUF1128 family protein	-
DXE46_RS10715	-	2078894..2079358 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DXE46_RS10720	-	2079365..2079640 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DXE46_RS10725	-	2079918..2081135 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DXE46_RS10730	vraR	2081248..2081877 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DXE46_RS10735	vraS	2081867..2082910 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DXE46_RS10740	liaF	2082907..2083608 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DXE46_RS10745	-	2083623..2084009 (-)	387	WP_001110182.1	hypothetical protein	-
DXE46_RS10750	map	2084226..2084984 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DXE46_RS10760	-	2085568..2086554 (+)	987	WP_000999712.1	FUSC family protein	-
DXE46_RS10765	-	2086743..2087156 (-)	414	WP_025174370.1	hypothetical protein	-
DXE46_RS10770	-	2087185..2087295 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1149881 DXE46_RS10735 WP_001017131.1 2081867..2082910(-) (vraS) [Staphylococcus aureus isolate 17_LA_343]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1149881 DXE46_RS10735 WP_001017131.1 2081867..2082910(-) (vraS) [Staphylococcus aureus isolate 17_LA_343]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1