Detailed information NTG1149838

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DXE64_RS13760
• Genome accession: NZ_LT992470
• Coordinates: 2670237..2671280 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 13_LA_301
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2665237..2676280

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE64_RS13725	-	2665852..2665962 (+)	111	WP_014937049.1	hypothetical protein	-
DXE64_RS13730	-	2665991..2666404 (+)	414	WP_025174370.1	hypothetical protein	-
DXE64_RS13735	-	2666593..2667579 (-)	987	WP_000999712.1	FUSC family protein	-
DXE64_RS13745	map	2668163..2668921 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DXE64_RS13750	-	2669138..2669524 (+)	387	WP_001110182.1	hypothetical protein	-
DXE64_RS13755	liaF	2669539..2670240 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DXE64_RS13760	vraS	2670237..2671280 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DXE64_RS13765	vraR	2671270..2671899 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DXE64_RS13770	-	2672012..2673229 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DXE64_RS13775	-	2673507..2673782 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
DXE64_RS13780	-	2673789..2674253 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DXE64_RS13785	-	2674400..2674600 (+)	201	WP_000180460.1	DUF1128 family protein	-
DXE64_RS13790	-	2674603..2675859 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1149838 DXE64_RS13760 WP_001017131.1 2670237..2671280(+) (vraS) [Staphylococcus aureus isolate 13_LA_301]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1149838 DXE64_RS13760 WP_001017131.1 2670237..2671280(+) (vraS) [Staphylococcus aureus isolate 13_LA_301]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1