Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   DXE64_RS12960 Genome accession   NZ_LT992470
Coordinates   2544217..2544933 (-) Length   238 a.a.
NCBI ID   WP_000688492.1    Uniprot ID   A0A7U7IEW1
Organism   Staphylococcus aureus isolate 13_LA_301     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2539217..2549933
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DXE64_RS12945 - 2540304..2541254 (+) 951 WP_000790325.1 LacI family DNA-binding transcriptional regulator -
  DXE64_RS12950 - 2541403..2542887 (+) 1485 WP_000141407.1 sucrose-6-phosphate hydrolase -
  DXE64_RS12955 - 2542884..2543843 (+) 960 WP_001253294.1 carbohydrate kinase family protein -
  DXE64_RS12960 agrA 2544217..2544933 (-) 717 WP_000688492.1 quorum-sensing response regulator AgrA Regulator
  DXE64_RS12965 agrC 2544952..2546244 (-) 1293 WP_001825886.1 quorum-sensing sensor histidine kinase AgrC -
  DXE64_RS12970 agrD 2546269..2546409 (-) 141 WP_001093929.1 cyclic lactone autoinducer peptide AgrD -
  DXE64_RS12975 agrB 2546406..2546975 (-) 570 WP_001105708.1 accessory gene regulator AgrB -
  DXE64_RS15270 hld 2547265..2547345 (+) 81 WP_000046022.1 delta-hemolysin -
  DXE64_RS12985 - 2547947..2548732 (-) 786 WP_000867947.1 carbon-nitrogen family hydrolase -
  DXE64_RS12990 - 2549040..2549666 (-) 627 WP_000522384.1 nitroreductase family protein -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27905.90 Da        Isoelectric Point: 6.0927

>NTDB_id=1149836 DXE64_RS12960 WP_000688492.1 2544217..2544933(-) (agrA) [Staphylococcus aureus isolate 13_LA_301]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=1149836 DXE64_RS12960 WP_000688492.1 2544217..2544933(-) (agrA) [Staphylococcus aureus isolate 13_LA_301]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACGTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCAGAATTAAGAACTCGAATTATAGATTGTTTAGAAACTGCACATACACGCTTACAATTAT
TATCAAAAGATAATAGCGTTGAAACGATTGAGTTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTCAGATGTCATAATAGCTTTGTCGTCAATCGTCATAATATCGAATCTATTG
ATTCGAAAGAGCGTATTGTTTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-120)

LytTr DNA-binding domain (LytTR)

(151-237)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7IEW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

100

100

1

Multiple sequence alignment