Detailed information NTG1149715

Bioinformatically predicted

Overview

• Name: comGA
• Type: Machinery gene
• Locus tag: DXE47_RS00500
• Genome accession: NZ_LT992468
• Coordinates: 73400..74374 (-)
• Length: 324 a.a.
• NCBI ID: WP_000697220.1
• Uniprot ID: W8U5L8
• Organism: Staphylococcus aureus isolate 12_LA_293
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 68400..79374

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE47_RS00460	gcvT	68901..69992 (-)	1092	WP_000093349.1	glycine cleavage system aminomethyltransferase GcvT	-
DXE47_RS00465	-	70151..70675 (-)	525	WP_001015120.1	shikimate kinase	-
DXE47_RS00470	-	70665..70811 (-)	147	WP_001789879.1	hypothetical protein	-
DXE47_RS00475	comGF	70908..71405 (-)	498	WP_001825340.1	competence type IV pilus minor pilin ComGF	Machinery gene
DXE47_RS00480	comGE	71323..71622 (-)	300	WP_000844413.1	hypothetical protein	Machinery gene
DXE47_RS00485	comGD	71609..72055 (-)	447	WP_001796473.1	competence type IV pilus minor pilin ComGD	Machinery gene
DXE47_RS00490	comGC	72033..72344 (-)	312	WP_000472256.1	competence type IV pilus major pilin ComGC	Machinery gene
DXE47_RS00495	comGB	72358..73428 (-)	1071	WP_000776425.1	competence type IV pilus assembly protein ComGB	Machinery gene
DXE47_RS00500	comGA	73400..74374 (-)	975	WP_000697220.1	competence type IV pilus ATPase ComGA	Machinery gene
DXE47_RS00505	-	74426..75049 (-)	624	WP_001223008.1	MBL fold metallo-hydrolase	-
DXE47_RS00510	-	75046..75375 (-)	330	WP_001018871.1	MTH1187 family thiamine-binding protein	-
DXE47_RS00515	-	75375..76361 (-)	987	WP_000161315.1	ROK family glucokinase	-
DXE47_RS00520	-	76358..76561 (-)	204	WP_000087559.1	YqgQ family protein	-
DXE47_RS00525	-	76542..78005 (-)	1464	WP_001017856.1	rhomboid family protein	-
DXE47_RS00530	-	78017..78556 (-)	540	WP_000164554.1	5-formyltetrahydrofolate cyclo-ligase	-
DXE47_RS00535	rpmG	78765..78914 (-)	150	WP_001265709.1	50S ribosomal protein L33	-

Sequence

Protein

• Length: 324 a.a.
• Molecular weight: 36897.96 Da
• Isoelectric Point: 8.8516

>NTDB_id=1149715 DXE47_RS00500 WP_000697220.1 73400..74374(-) (comGA) [Staphylococcus aureus isolate 12_LA_293]
MKILFQEIINKAIEMKASDVHFIPVKNEVSIKFRINDNLEQYEQIGNSIYQKLLVYMKFQAGLDVSTQQVAQSGRYSYHF
NKIYFLRISTLPLSLGQESCVIRIVPQFFQQQKSTYKFNDFKHLMNKKQGLLLFSGPTGSGKSTLMYQMVSYANKALNLN
VISIEDPVEMQIPGIVQINVNDKAGINYVNSFKAILRCDPDVILIGEIRDKDVAKCVIQASLSGHLVLTTLHATDCKGAI
LRLLEMGISVQELIQATNLIINQRLVTTIKQQRQLVCEILSQQQLRYFFSHNHSLPSSFKNLEDKLDDMTKAGVICETTM
DKYI

Nucleotide

• Length: 975 bp

>NTDB_id=1149715 DXE47_RS00500 WP_000697220.1 73400..74374(-) (comGA) [Staphylococcus aureus isolate 12_LA_293]
TTGAAGATTCTATTTCAAGAAATAATTAATAAAGCGATAGAAATGAAAGCGAGTGATGTACATTTTATTCCAGTTAAAAA
TGAAGTAAGTATTAAATTTAGAATTAATGATAACTTGGAGCAGTACGAACAAATTGGGAATAGCATTTATCAAAAGTTAT
TAGTTTATATGAAGTTTCAAGCTGGGCTTGATGTTTCTACACAGCAAGTCGCACAGAGCGGTCGATATAGTTACCATTTC
AATAAAATATATTTTTTGAGAATATCAACTTTACCATTGTCACTTGGCCAAGAAAGTTGTGTTATCAGAATTGTACCTCA
ATTTTTTCAACAACAGAAATCAACTTATAAATTCAATGATTTTAAACACCTCATGAATAAGAAACAAGGATTACTATTGT
TTAGTGGGCCAACTGGTTCAGGAAAGAGTACATTAATGTATCAAATGGTCTCATACGCGAATAAAGCCTTGAATTTAAAT
GTAATTTCTATAGAGGATCCTGTAGAGATGCAAATTCCTGGTATTGTCCAAATTAATGTGAATGATAAAGCTGGCATTAA
CTATGTAAATTCGTTTAAAGCTATTTTAAGATGTGATCCTGATGTTATTTTAATAGGTGAAATCAGAGATAAAGATGTTG
CCAAGTGTGTTATACAGGCTAGTTTAAGTGGTCACCTTGTTCTGACTACATTGCATGCAACTGATTGTAAAGGTGCTATT
TTAAGGCTATTAGAAATGGGCATTTCTGTACAAGAATTGATACAGGCAACTAACTTAATTATAAACCAACGACTTGTAAC
TACTATTAAGCAACAGCGACAATTAGTATGTGAAATTCTATCTCAGCAACAACTCCGATATTTCTTTTCCCATAATCATT
CATTACCATCATCATTTAAGAACTTAGAAGATAAACTTGATGATATGACAAAAGCAGGTGTCATTTGTGAAACTACAATG
GATAAATACATTTAA

Domains

Predicted by InterproScan.

• Type II/IV secretion system protein (T2SSE) (7-267)

3D structure

• AlphaFold DB: W8U5L8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGA	Staphylococcus aureus MW2	100	100	1
comGA	Staphylococcus aureus N315	100	100	1