Detailed information NTG1149614

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DXE62_RS13235
• Genome accession: NZ_LT992465
• Coordinates: 2588805..2589848 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 6_LA_232
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2583805..2594848

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE62_RS13200	-	2584420..2584531 (+)	112	Protein_2511	hypothetical protein	-
DXE62_RS13205	-	2584560..2584973 (+)	414	WP_025174370.1	hypothetical protein	-
DXE62_RS13210	-	2585162..2586148 (-)	987	WP_000999712.1	FUSC family protein	-
DXE62_RS13220	map	2586732..2587490 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DXE62_RS13225	-	2587707..2588092 (+)	386	Protein_2515	hypothetical protein	-
DXE62_RS13230	liaF	2588107..2588808 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DXE62_RS13235	vraS	2588805..2589848 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DXE62_RS13240	vraR	2589838..2590467 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DXE62_RS13245	-	2590580..2591797 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DXE62_RS13250	-	2592075..2592350 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
DXE62_RS13255	-	2592357..2592821 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DXE62_RS13260	-	2592968..2593168 (+)	201	WP_000180460.1	DUF1128 family protein	-
DXE62_RS13265	-	2593171..2594427 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1149614 DXE62_RS13235 WP_001017131.1 2588805..2589848(+) (vraS) [Staphylococcus aureus isolate 6_LA_232]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1149614 DXE62_RS13235 WP_001017131.1 2588805..2589848(+) (vraS) [Staphylococcus aureus isolate 6_LA_232]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1