Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   DXE62_RS12450 Genome accession   NZ_LT992465
Coordinates   2461833..2462549 (-) Length   238 a.a.
NCBI ID   WP_000688492.1    Uniprot ID   A0A7U7IEW1
Organism   Staphylococcus aureus isolate 6_LA_232     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2456833..2467549
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DXE62_RS12435 - 2457920..2458870 (+) 951 WP_000790325.1 LacI family DNA-binding transcriptional regulator -
  DXE62_RS12440 - 2459019..2460503 (+) 1485 WP_000141407.1 sucrose-6-phosphate hydrolase -
  DXE62_RS12445 - 2460500..2461459 (+) 960 WP_001253294.1 carbohydrate kinase family protein -
  DXE62_RS12450 agrA 2461833..2462549 (-) 717 WP_000688492.1 quorum-sensing response regulator AgrA Regulator
  DXE62_RS12455 agrC 2462568..2463860 (-) 1293 WP_001825886.1 quorum-sensing sensor histidine kinase AgrC -
  DXE62_RS12460 agrD 2463885..2464025 (-) 141 WP_001093929.1 cyclic lactone autoinducer peptide AgrD -
  DXE62_RS12465 agrB 2464022..2464591 (-) 570 WP_001105708.1 accessory gene regulator AgrB -
  DXE62_RS15090 hld 2464881..2464961 (+) 81 WP_000046022.1 delta-hemolysin -
  DXE62_RS12475 - 2465563..2466348 (-) 786 WP_000867947.1 carbon-nitrogen family hydrolase -
  DXE62_RS12480 - 2466656..2467282 (-) 627 WP_000522384.1 nitroreductase family protein -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27905.90 Da        Isoelectric Point: 6.0927

>NTDB_id=1149612 DXE62_RS12450 WP_000688492.1 2461833..2462549(-) (agrA) [Staphylococcus aureus isolate 6_LA_232]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=1149612 DXE62_RS12450 WP_000688492.1 2461833..2462549(-) (agrA) [Staphylococcus aureus isolate 6_LA_232]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACGTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCAGAATTAAGAACTCGAATTATAGATTGTTTAGAAACTGCACATACACGCTTACAATTAT
TATCAAAAGATAATAGCGTTGAAACGATTGAGTTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTCAGATGTCATAATAGCTTTGTCGTCAATCGTCATAATATCGAATCTATTG
ATTCGAAAGAGCGTATTGTTTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-120)

LytTr DNA-binding domain (LytTR)

(151-237)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7IEW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

100

100

1

Multiple sequence alignment