Detailed information NTG1149480

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DXE65_RS09315
• Genome accession: NZ_LT992462
• Coordinates: 1734800..1735843 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 5_3949
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1729800..1740843

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE65_RS09285	-	1730221..1731477 (-)	1257	WP_074347694.1	aminopeptidase	-
DXE65_RS09290	-	1731480..1731680 (-)	201	WP_000180460.1	DUF1128 family protein	-
DXE65_RS09295	-	1731827..1732291 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DXE65_RS09300	-	1732298..1732573 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DXE65_RS09305	-	1732851..1734068 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DXE65_RS09310	vraR	1734181..1734810 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DXE65_RS09315	vraS	1734800..1735843 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DXE65_RS09320	liaF	1735840..1736541 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DXE65_RS09325	-	1736556..1736942 (-)	387	WP_001110182.1	hypothetical protein	-
DXE65_RS09330	map	1737159..1737917 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DXE65_RS09340	-	1738501..1739487 (+)	987	WP_000999712.1	FUSC family protein	-
DXE65_RS09345	-	1739676..1740089 (-)	414	WP_025174370.1	hypothetical protein	-
DXE65_RS09350	-	1740118..1740228 (-)	111	WP_031914462.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1149480 DXE65_RS09315 WP_001017131.1 1734800..1735843(-) (vraS) [Staphylococcus aureus isolate 5_3949]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1149480 DXE65_RS09315 WP_001017131.1 1734800..1735843(-) (vraS) [Staphylococcus aureus isolate 5_3949]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1