Detailed information NTG1149321

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DXE63_RS07730
• Genome accession: NZ_LT992458
• Coordinates: 1476349..1477392 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 7_4623
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1471349..1482392

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE63_RS07695	-	1472074..1472184 (+)	111	WP_014937049.1	hypothetical protein	-
DXE63_RS07700	-	1472213..1472626 (+)	414	WP_025174370.1	hypothetical protein	-
DXE63_RS07705	-	1472815..1473801 (-)	987	WP_000999712.1	FUSC family protein	-
DXE63_RS07715	map	1474275..1475033 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DXE63_RS07720	-	1475250..1475636 (+)	387	WP_001110182.1	hypothetical protein	-
DXE63_RS07725	liaF	1475651..1476352 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DXE63_RS07730	vraS	1476349..1477392 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DXE63_RS07735	vraR	1477382..1478011 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DXE63_RS07740	-	1478124..1479341 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DXE63_RS07745	-	1479619..1479894 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
DXE63_RS07750	-	1479901..1480365 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DXE63_RS07755	-	1480512..1480712 (+)	201	WP_000180460.1	DUF1128 family protein	-
DXE63_RS07760	-	1480715..1481971 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1149321 DXE63_RS07730 WP_001017131.1 1476349..1477392(+) (vraS) [Staphylococcus aureus isolate 7_4623]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1149321 DXE63_RS07730 WP_001017131.1 1476349..1477392(+) (vraS) [Staphylococcus aureus isolate 7_4623]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1