Detailed information NTG1147498

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: CKV85_RS08545
• Genome accession: NZ_LT906454
• Coordinates: 1759861..1762119 (+)
• Length: 752 a.a.
• NCBI ID: WP_095123317.1
• Uniprot ID: -
• Organism: Streptococcus acidominimus strain NCTC11291
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1762211..1766044	1759861..1762119	flank	92

Gene organization within MGE regions

Location: 1759861..1766044

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CKV85_RS08545 (SAMEA4504048_01819)	clpE	1759861..1762119 (+)	2259	WP_095123317.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
CKV85_RS08550	-	1762211..1763780 (+)	1570	Protein_1698	IS3 family transposase	-
CKV85_RS08555 (SAMEA4504048_01822)	-	1764191..1764562 (-)	372	WP_419865782.1	ECF transporter S component	-
CKV85_RS08560 (SAMEA4504048_01823)	-	1764842..1766044 (+)	1203	WP_331711877.1	IS110 family transposase	-

Sequence

Protein

• Length: 752 a.a.
• Molecular weight: 83848.13 Da
• Isoelectric Point: 4.9507

>NTDB_id=1147498 CKV85_RS08545 WP_095123317.1 1759861..1762119(+) (clpE) [Streptococcus acidominimus strain NCTC11291]
MLCQNCKLNESTIHLYTNVNGKQKQVDLCQNCYQIMKTEPKNGFLSHLGQEQASSSLNPFFDDFFGDLNNFRAFSGDLPN
TPKTQTGGRGGNGDTGNRIPNRPQGPAPQKPQGLLEEFGINITDIARRGDIDPVIGRDDEILRVIEILNRRTKNNPVLIG
EPGVGKTAVVEGLAQKIVDSDVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRNRQDVILFIDEIHEIVGAG
NAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHHVKYST
DAIEAAAILSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPQEIDQRLIEAENLKAQATRDEDYERAAYFRDQIAKYK
EIQAQKVDDQDTPVVTEKNIEAIIEQKTSIPVGELKEKEQSQLIHLADDLKSHVIGQDDAVDRIAKAIRRNRVGLGSPNR
PIGSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILL
DEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAREGRTNSVLNQLGDFFSPEFMN
RFDGIIEFKALEKENLLHIVDLMLEDVNKRLAMNGLHLEVTDKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDFYLE
NPSEKELRAIMTSNGKIVIKSSTKVEATAEEK

Nucleotide

• Length: 2259 bp

>NTDB_id=1147498 CKV85_RS08545 WP_095123317.1 1759861..1762119(+) (clpE) [Streptococcus acidominimus strain NCTC11291]
ATGCTTTGTCAAAATTGCAAATTAAACGAATCAACCATCCATTTATATACTAATGTTAATGGTAAACAAAAACAAGTTGA
TCTCTGTCAAAATTGCTATCAAATTATGAAAACAGAGCCTAAAAATGGTTTTCTGTCCCATTTAGGACAAGAACAGGCTT
CTTCATCACTAAACCCATTCTTCGATGATTTCTTTGGAGACCTTAACAATTTCCGTGCTTTTAGTGGTGATTTGCCTAAC
ACTCCTAAGACACAGACGGGAGGCCGAGGCGGTAACGGCGATACAGGAAATAGGATTCCAAATCGCCCTCAAGGACCCGC
TCCGCAAAAACCTCAAGGACTACTCGAAGAATTTGGGATTAACATTACTGACATTGCCCGCCGTGGCGACATTGATCCTG
TCATCGGTCGTGACGATGAAATCCTTCGTGTCATTGAAATTCTCAACCGTCGTACCAAAAATAATCCAGTCCTCATCGGC
GAACCCGGTGTTGGTAAAACAGCTGTTGTTGAAGGATTGGCTCAAAAAATCGTTGATTCAGATGTCCCTCAAAAACTCCA
AGGAAAACAAGTCATCCGACTGGATGTGGTTAGTTTAGTACAAGGTACTGGAATCCGCGGACAGTTTGAAGAGCGTATGC
AAAAACTGATGGATGAAATCCGCAACCGCCAAGATGTTATTCTCTTTATTGATGAAATCCATGAAATCGTCGGTGCAGGT
AATGCTGGTGATGGTAATATGGATGCGGGTAACATCTTGAAACCAGCGCTAGCCCGCGGTGAGTTGCAACTCGTTGGTGC
AACCACACTCAATGAATACCGCATTATCGAAAAAGATGCCGCTCTGGAACGTCGTATGCAACCCGTTAAAGTTGACGAAC
CAAGTGTGGAAGAAACCATTACAATCTTAAAAGGCATTCAACCGAAATACGAAGATTACCATCATGTCAAATATAGCACT
GATGCTATTGAGGCTGCTGCTATCCTTTCTAACCGCTACATTCAAGATCGTTTCTTGCCTGATAAAGCTATTGATCTACT
AGATGAAGCCGGTTCTAAAATGAATCTGACTCTTAATTTTGTTGATCCACAAGAAATTGACCAGCGTCTCATCGAGGCTG
AAAATCTCAAGGCACAAGCAACTCGTGACGAAGATTACGAACGTGCTGCCTACTTCCGTGATCAAATCGCTAAATACAAA
GAAATACAAGCTCAAAAAGTCGATGATCAAGACACACCTGTTGTGACAGAAAAAAATATCGAAGCCATCATCGAACAAAA
AACAAGCATTCCAGTTGGTGAGCTCAAAGAAAAAGAGCAAAGTCAATTGATTCACCTAGCAGACGATCTCAAAAGTCATG
TTATCGGACAAGATGATGCTGTCGATAGAATTGCCAAAGCTATCCGCCGTAATCGTGTTGGGCTAGGGTCTCCAAACCGA
CCAATAGGAAGCTTCCTCTTTGTCGGACCAACTGGTGTCGGTAAGACGGAACTGTCTAAACAGCTGGCTATCGAGCTCTT
CGGTTCTGCTGATAGCATGATTCGATTTGACATGTCAGAGTATATGGAAAAACACTCTGTTGCAAAACTGGTCGGGGCTC
CTCCAGGATATGTTGGTTACGAAGAAGCTGGTCAATTGACTGAAAAAGTACGCCGTAACCCATACTCACTAATCTTGCTT
GACGAGGTTGAAAAAGCTCACCCAGATGTCATGCATATGTTCCTTCAAGTCTTGGATGATGGTCGTCTAACGGACGGTCA
AGGGCGCACGGTCAGCTTTAAAGACACTATTATCATTATGACTTCTAATGCGGGAACTGGTAAAGTTGAAGCTTCAGTCG
GATTTGGTGCCGCTCGTGAAGGACGCACTAATTCCGTTCTCAATCAACTCGGAGACTTCTTTAGTCCAGAATTCATGAAC
CGTTTTGACGGTATTATTGAATTTAAAGCACTTGAAAAAGAAAATCTCCTTCACATCGTTGATCTAATGCTCGAAGATGT
GAACAAACGTCTTGCAATGAACGGTCTTCACTTGGAAGTAACTGATAAAGTCAAAGAAAAACTAGTTGACCTAGGGTATG
ACCCTAAAATGGGAGCTCGTCCGCTCCGTCGTACCATCCAAGAGCATATCGAAGATGCTATAACAGACTTTTATCTCGAA
AACCCTTCTGAAAAAGAACTTCGTGCTATCATGACTTCTAACGGAAAAATCGTTATTAAATCAAGCACTAAAGTTGAAGC
AACTGCAGAAGAAAAATAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (295-392)

• ATPase family associated with various cellular activities (AAA) (AAA) (157-276)

• AAA domain (Cdc48 subfamily) (AAA_2) (480-643)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (651-725)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	87.217	99.867	0.871
clpE	Streptococcus pneumoniae Rx1	82.846	100	0.828
clpE	Streptococcus pneumoniae D39	82.846	100	0.828
clpE	Streptococcus pneumoniae R6	82.846	100	0.828
clpE	Streptococcus pneumoniae TIGR4	82.846	100	0.828
clpC	Lactococcus lactis subsp. cremoris KW2	76.455	100	0.769
clpC	Bacillus subtilis subsp. subtilis str. 168	52.308	86.436	0.452
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	45.029	90.957	0.41
clpC	Streptococcus mutans UA159	47.284	83.245	0.394
clpC	Streptococcus pneumoniae Rx1	47.504	82.58	0.392
clpC	Streptococcus pneumoniae D39	47.504	82.58	0.392
clpC	Streptococcus pneumoniae TIGR4	47.343	82.58	0.391
clpC	Streptococcus thermophilus LMD-9	46.388	82.846	0.384
clpC	Streptococcus thermophilus LMG 18311	46.154	82.979	0.383