Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   BCM300_RS04365 Genome accession   NZ_LT837687
Coordinates   885838..887622 (+) Length   594 a.a.
NCBI ID   WP_089086944.1    Uniprot ID   A0A238GVQ3
Organism   Helicobacter pylori isolate BCM-300     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 880838..892622
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BCM300_RS04335 (BCM300_00861) motB 881556..882329 (+) 774 WP_001085350.1 flagellar motor protein MotB -
  BCM300_RS04340 (BCM300_00862) - 882326..882772 (+) 447 WP_001081239.1 hypothetical protein -
  BCM300_RS04345 (BCM300_00863) - 882886..884547 (+) 1662 WP_089086942.1 glycine betaine ABC transporter substrate-binding protein -
  BCM300_RS04350 (BCM300_00864) - 884551..885201 (+) 651 WP_089086943.1 ATP-binding cassette domain-containing protein -
  BCM300_RS04355 - 885205..885384 (-) 180 WP_001872805.1 hypothetical protein -
  BCM300_RS04360 (BCM300_00865) - 885376..885837 (+) 462 WP_000437205.1 hypothetical protein -
  BCM300_RS04365 (BCM300_00866) uvrC 885838..887622 (+) 1785 WP_089086944.1 excinuclease ABC subunit UvrC Machinery gene
  BCM300_RS04370 (BCM300_00867) - 887633..888898 (+) 1266 WP_079359326.1 homoserine dehydrogenase -
  BCM300_RS04375 (BCM300_00868) - 888899..889243 (+) 345 WP_001974044.1 YraN family protein -
  BCM300_RS04380 (BCM300_00869) trxA 889332..889652 (+) 321 WP_000020199.1 thioredoxin -
  BCM300_RS04385 (BCM300_00870) trxB 889658..890593 (+) 936 WP_089086945.1 thioredoxin-disulfide reductase -
  BCM300_RS04390 (BCM300_00871) - 890969..891790 (+) 822 WP_089086946.1 glycosyltransferase family 25 protein -
  BCM300_RS04395 (BCM300_00872) - 892008..892256 (-) 249 WP_000790555.1 RNA-binding protein -
  BCM300_RS08385 - 892410..892586 (+) 177 WP_000510516.1 hypothetical protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68771.92 Da        Isoelectric Point: 9.6703

>NTDB_id=1146341 BCM300_RS04365 WP_089086944.1 885838..887622(+) (uvrC) [Helicobacter pylori isolate BCM-300]
MADLLSSLKNLSSSSGVYQYFDKNHQLLYIGKAKNLKKRIKSYFSVRNNEITPNPRTSLRVQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
DCSNEVLKELQEFISHQYSKKIALNIPKKRDKLALIEIAMKNAQEIFSQEKTSNEDLILEEVRSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTTSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRK

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=1146341 BCM300_RS04365 WP_089086944.1 885838..887622(+) (uvrC) [Helicobacter pylori isolate BCM-300]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAGTAGTAGTGGCGTGTATCAATATTTTGATAAAAACCACCAATT
ACTCTACATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTGTCCGTAATAATGAAATCACGCCCA
ATCCTCGCACAAGCTTACGCGTCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTGGAAAATTCTTTGATCAAGCAGCTCAAGCCTAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATCTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTCACGAGCGGGGCTAAGGACATTTTGGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAGTAATTTGCGTTTTGAAGAAGCTCTGATTTATAGGGATAGGATAGCTAAAATCCAAAAAATC
GCCCCCTTCACTTGCATGGATTTGGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGTGGGAACAACAAGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAGGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCTGAACAGATCTTATTGAGC
GATTGCTCTAATGAGGTGCTTAAAGAATTGCAAGAATTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAATATCCC
TAAAAAGCGCGATAAACTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGTCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGTGCGATCGCTTTTCAATTTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGCCTTTCAAAAAAACTCTTATCGGCG
TTACCATTTAAAAGGCTCTAACGAATACGATCAAATGAGCGAATTGCTCACTAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATAGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCCATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGACTAGTAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAACAGGAAAAAAA
CGCCGTTTTAAAAAAACGAAAATAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A238GVQ3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

95.784

99.832

0.956

Multiple sequence alignment