Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   EDCC5055_RS00220 Genome accession   NZ_LT671859
Coordinates   47617..48966 (-) Length   449 a.a.
NCBI ID   WP_073546223.1    Uniprot ID   -
Organism   Staphylococcus aureus isolate Clinical isolate     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 39202..48966 47617..48966 within 0


Gene organization within MGE regions


Location: 39202..48966
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EDCC5055_RS00180 (EDCC5055_00035) mecA 39202..41211 (-) 2010 WP_078150679.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  EDCC5055_RS00185 (EDCC5055_00036) - 41308..42294 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  EDCC5055_RS00190 (EDCC5055_00037) - 42284..42526 (+) 243 Protein_32 type I restriction enzyme endonuclease domain-containing protein -
  EDCC5055_RS00195 (EDCC5055_00038) - 42517..44127 (-) 1611 Protein_33 IS1182 family transposase -
  EDCC5055_RS00200 (EDCC5055_00039) - 44176..44682 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  EDCC5055_RS00205 (EDCC5055_00040) - 44697..45008 (-) 312 WP_000700851.1 DUF960 family protein -
  EDCC5055_RS00210 (EDCC5055_00042) - 45095..45445 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  EDCC5055_RS00215 (EDCC5055_00043) ccrB 45967..47595 (-) 1629 WP_001186608.1 cassette chromosome recombinase CcrB Machinery gene
  EDCC5055_RS00220 (EDCC5055_00044) ccrA 47617..48966 (-) 1350 WP_073546223.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52717.36 Da        Isoelectric Point: 10.0062

>NTDB_id=1146024 EDCC5055_RS00220 WP_073546223.1 47617..48966(-) (ccrA) [Staphylococcus aureus isolate Clinical isolate]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYRVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
HGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1146024 EDCC5055_RS00220 WP_073546223.1 47617..48966(-) (ccrA) [Staphylococcus aureus isolate Clinical isolate]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
TTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATATCGCGTTCATATCTTAAGTGTGCATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
CACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Recombinase (Recombinase)

(169-250)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.55

100

0.976
  ccrA Staphylococcus aureus COL

75.056

100

0.751

Multiple sequence alignment