Detailed information NTG1144896

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LLA12_RS11920
• Genome accession: NZ_LT599049
• Coordinates: 2429686..2430714 (-)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis subsp. lactis strain A12
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2424686..2435714

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLA12_RS11895 (LLA12_02522)	-	2424972..2425469 (-)	498	WP_003132662.1	nitroreductase family protein	-
LLA12_RS11900 (LLA12_02523)	-	2425456..2425665 (-)	210	WP_003132661.1	hypothetical protein	-
LLA12_RS11905 (LLA12_02524)	-	2425662..2426489 (-)	828	WP_010906344.1	radical SAM protein	-
LLA12_RS11910 (LLA12_02525)	-	2426482..2428605 (-)	2124	WP_021723357.1	radical SAM protein	-
LLA12_RS11915 (LLA12_02526)	-	2428708..2429565 (-)	858	WP_021723356.1	transcription regulator	-
LLA12_RS11920 (LLA12_02527)	sepM	2429686..2430714 (-)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
LLA12_RS11925 (LLA12_02528)	coaD	2430701..2431198 (-)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
LLA12_RS11930 (LLA12_02529)	rsmD	2431246..2431785 (-)	540	WP_015427191.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
LLA12_RS11935 (LLA12_02530)	-	2431956..2433176 (-)	1221	WP_021723355.1	MDR family MFS transporter	-
LLA12_RS11940 (LLA12_02531)	lmrP	2433258..2434484 (-)	1227	WP_012898648.1	multidrug efflux MFS transporter LmrP	-
LLA12_RS11945 (LLA12_02532)	-	2434672..2435166 (+)	495	WP_012898649.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=1144896 LLA12_RS11920 WP_003132657.1 2429686..2430714(-) (sepM) [Lactococcus lactis subsp. lactis strain A12]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=1144896 LLA12_RS11920 WP_003132657.1 2429686..2430714(-) (sepM) [Lactococcus lactis subsp. lactis strain A12]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTATCCAACGAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGGAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTCCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTATAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAACTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGAAAAACAGGAATTGGGA
TCAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCAAAAGTTACTGTCAACGCGGGTTCAATCGGTGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
AACGATTGAACATGACGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGCAAAGAAGGGGCAA
AGGTCTTCTTAGTGCCTGACTCAGGCACCAAAAAGGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCCGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491