Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   BN6763_RS13830 Genome accession   NZ_LT571449
Coordinates   2739234..2740580 (+) Length   448 a.a.
NCBI ID   WP_000816499.1    Uniprot ID   Q9R3W9
Organism   Staphylococcus epidermidis isolate BPH0662     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2705428..2760392 2739234..2740580 within 0


Gene organization within MGE regions


Location: 2705428..2760392
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BN6763_RS13650 - 2705428..2706240 (-) 813 WP_002504699.1 abortive infection system antitoxin AbiGi family protein -
  BN6763_RS13655 - 2706431..2707945 (+) 1515 WP_002504700.1 type I restriction-modification system subunit M -
  BN6763_RS13660 - 2707935..2709209 (+) 1275 WP_002504701.1 restriction endonuclease subunit S -
  BN6763_RS13665 - 2709193..2712312 (+) 3120 WP_002504702.1 type I restriction endonuclease subunit R -
  BN6763_RS13670 - 2712390..2712713 (-) 324 WP_001176049.1 PepSY domain-containing protein -
  BN6763_RS13675 - 2713107..2713328 (-) 222 WP_002504703.1 hypothetical protein -
  BN6763_RS13680 - 2713277..2713720 (-) 444 WP_000941333.1 hypothetical protein -
  BN6763_RS13685 - 2713782..2714309 (-) 528 WP_002504704.1 hypothetical protein -
  BN6763_RS13690 - 2714444..2714932 (-) 489 WP_000393586.1 hypothetical protein -
  BN6763_RS13695 - 2714948..2715238 (-) 291 WP_000065261.1 hypothetical protein -
  BN6763_RS13700 - 2715295..2716167 (-) 873 WP_000373149.1 HTH domain-containing protein -
  BN6763_RS13705 - 2716337..2716783 (-) 447 WP_002504705.1 JAB domain-containing protein -
  BN6763_RS13710 - 2716804..2717310 (-) 507 WP_000849085.1 DUF1643 domain-containing protein -
  BN6763_RS13715 - 2717326..2717637 (-) 312 WP_001083108.1 DUF960 family protein -
  BN6763_RS13720 - 2717733..2718071 (-) 339 WP_063964250.1 SAUGI family uracil-DNA glycosylase inhibitor -
  BN6763_RS13725 ccrC 2718177..2719853 (-) 1677 WP_002504707.1 cassette chromosome recombinase CcrC -
  BN6763_RS13730 - 2720078..2721721 (-) 1644 WP_002504708.1 DUF5906 domain-containing protein -
  BN6763_RS13735 - 2721718..2722089 (-) 372 WP_002437511.1 hypothetical protein -
  BN6763_RS13740 - 2722082..2723191 (-) 1110 WP_002437509.1 DNA polymerase -
  BN6763_RS13745 - 2723361..2725373 (-) 2013 WP_012088687.1 hypothetical protein -
  BN6763_RS13750 - 2725535..2726464 (-) 930 WP_002504713.1 helix-turn-helix transcriptional regulator -
  BN6763_RS13755 - 2726545..2726973 (+) 429 WP_000671997.1 VOC family protein -
  BN6763_RS13760 - 2727033..2727707 (-) 675 Protein_2604 IS6 family transposase -
  BN6763_RS13765 - 2727918..2729108 (+) 1191 WP_000716034.1 YbfB/YjiJ family MFS transporter -
  BN6763_RS13770 - 2729095..2729961 (+) 867 WP_002504710.1 LysR family transcriptional regulator -
  BN6763_RS13775 - 2729974..2731044 (+) 1071 WP_001054882.1 NAD(P)H-dependent flavin oxidoreductase -
  BN6763_RS13780 - 2731209..2731568 (+) 360 WP_000432280.1 DUF4870 domain-containing protein -
  BN6763_RS13785 - 2731806..2732579 (-) 774 WP_000998885.1 hypothetical protein -
  BN6763_RS13790 - 2732896..2733060 (-) 165 WP_001028954.1 hypothetical protein -
  BN6763_RS13795 - 2733265..2734098 (-) 834 WP_000694291.1 CPBP family intramembrane glutamic endopeptidase -
  BN6763_RS13800 - 2734135..2734461 (-) 327 WP_000624048.1 helix-turn-helix domain-containing protein -
  BN6763_RS13805 - 2734793..2735365 (-) 573 WP_000489177.1 ADP-ribosyltransferase -
  BN6763_RS13810 - 2735418..2736467 (-) 1050 WP_000613217.1 hypothetical protein -
  BN6763_RS13815 ssb 2736605..2736889 (+) 285 WP_000659554.1 cassette chromosome ssDNA-binding protein -
  BN6763_RS13820 cch1 2736889..2738676 (+) 1788 WP_000181743.1 cassette chromosome replicative helicase -
  BN6763_RS13825 - 2738766..2739041 (+) 276 WP_001791132.1 hypothetical protein -
  BN6763_RS13830 ccrA 2739234..2740580 (+) 1347 WP_000816499.1 cassette chromosome recombinase CcrA Machinery gene
  BN6763_RS13835 ccrB 2740601..2742229 (+) 1629 WP_001186596.1 cassette chromosome recombinase CcrB Machinery gene
  BN6763_RS13840 - 2742700..2743050 (+) 351 WP_000171449.1 SAUGI family uracil-DNA glycosylase inhibitor -
  BN6763_RS13850 - 2743135..2743446 (+) 312 WP_000833212.1 DUF960 family protein -
  BN6763_RS13855 - 2743465..2743986 (+) 522 WP_000836008.1 DUF1643 domain-containing protein -
  BN6763_RS13860 - 2743988..2744194 (+) 207 WP_001077283.1 hypothetical protein -
  BN6763_RS13865 - 2744187..2744510 (+) 324 WP_000088091.1 JAB domain-containing protein -
  BN6763_RS13870 - 2744705..2746597 (+) 1893 WP_063964251.1 site-specific integrase -
  BN6763_RS13875 - 2746604..2746981 (+) 378 WP_001041908.1 DUF6262 family protein -
  BN6763_RS13880 - 2747219..2747584 (+) 366 WP_000159127.1 ArsR/SmtB family transcription factor -
  BN6763_RS13885 - 2747577..2749991 (+) 2415 WP_000378485.1 cadmium-translocating P-type ATPase CadA -
  BN6763_RS13890 - 2750072..2750688 (+) 617 Protein_2629 CadD family cadmium resistance transporter -
  BN6763_RS13900 - 2750962..2751600 (-) 639 Protein_2630 sulfite exporter TauE/SafE family protein -
  BN6763_RS13905 cstR 2751600..2751860 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  BN6763_RS13910 - 2751996..2753060 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  BN6763_RS13915 cstB 2753093..2754427 (+) 1335 Protein_2633 persulfide dioxygenase-sulfurtransferase CstB -
  BN6763_RS13925 - 2754541..2755671 (-) 1131 WP_010922808.1 ROK family transcriptional regulator -
  BN6763_RS13930 psm-mec 2756005..2756073 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  BN6763_RS13935 mecI 2756158..2756529 (-) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  BN6763_RS13940 mecR1 2756529..2758286 (-) 1758 WP_002504642.1 beta-lactam sensor/signal transducer MecR1 -
  BN6763_RS13945 mecA 2758383..2760392 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 52138.19 Da        Isoelectric Point: 10.1760

>NTDB_id=1143875 BN6763_RS13830 WP_000816499.1 2739234..2740580(+) (ccrA) [Staphylococcus epidermidis isolate BPH0662]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=1143875 BN6763_RS13830 WP_000816499.1 2739234..2740580(+) (ccrA) [Staphylococcus epidermidis isolate BPH0662]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(168-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9R3W9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

78.174

100

0.783
  ccrA Staphylococcus aureus N315

72.383

100

0.725

Multiple sequence alignment