Detailed information NTG1142887

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQN68_RS03245
• Genome accession: NZ_LS483522
• Coordinates: 605215..606252 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8224
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 600215..611252

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN68_RS03220 (NCTC8224_00632)	-	600479..601810 (+)	1332	WP_011285641.1	dipeptidase	-
DQN68_RS03225 (NCTC8224_00633)	arcC	601830..602780 (+)	951	WP_010922501.1	carbamate kinase	-
DQN68_RS03230 (NCTC8224_00634)	asnA	603093..604085 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQN68_RS03235 (NCTC8224_00635)	rsmD	604208..604747 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQN68_RS03240 (NCTC8224_00636)	coaD	604737..605228 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQN68_RS03245 (NCTC8224_00637)	sepM	605215..606252 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQN68_RS03250 (NCTC8224_00638)	-	606667..607644 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQN68_RS03255 (NCTC8224_00640)	-	608092..608712 (+)	621	WP_002992791.1	YutD family protein	-
DQN68_RS03260 (NCTC8224_00641)	rlmN	608716..609795 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQN68_RS03265 (NCTC8224_00642)	-	609877..610503 (-)	627	WP_002983834.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1142887 DQN68_RS03245 WP_010922499.1 605215..606252(+) (sepM) [Streptococcus pyogenes strain NCTC8224]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1142887 DQN68_RS03245 WP_010922499.1 605215..606252(+) (sepM) [Streptococcus pyogenes strain NCTC8224]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693