Detailed information NTG1142510

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DQL46_RS05060
• Genome accession: NZ_LS483482
• Coordinates: 1084472..1085515 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain NCTC12217
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1079472..1090515

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL46_RS05035 (NCTC12217_01024)	-	1079762..1081123 (-)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-
DQL46_RS05040 (NCTC12217_01025)	-	1081257..1082237 (-)	981	WP_070648298.1	FUSC family protein	-
DQL46_RS05045 (NCTC12217_01026)	map	1082482..1083237 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
DQL46_RS05050 (NCTC12217_01027)	-	1083363..1083749 (+)	387	WP_002477960.1	hypothetical protein	-
DQL46_RS05055 (NCTC12217_01028)	liaF	1083774..1084475 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
DQL46_RS05060 (NCTC12217_01029)	vraS	1084472..1085515 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
DQL46_RS05065 (NCTC12217_01030)	vraR	1085505..1086134 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
DQL46_RS05070 (NCTC12217_01031)	-	1086307..1087536 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
DQL46_RS05075 (NCTC12217_01032)	-	1087739..1088023 (-)	285	WP_080606548.1	YtxH domain-containing protein	-
DQL46_RS05080 (NCTC12217_01033)	-	1088030..1088494 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
DQL46_RS05085 (NCTC12217_01034)	-	1088658..1088843 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
DQL46_RS05090 (NCTC12217_01035)	-	1088856..1090094 (+)	1239	WP_002461326.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=1142510 DQL46_RS05060 WP_002461334.1 1084472..1085515(+) (vraS) [Staphylococcus lugdunensis strain NCTC12217]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=1142510 DQL46_RS05060 WP_002461334.1 1084472..1085515(+) (vraS) [Staphylococcus lugdunensis strain NCTC12217]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911