Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   DQN71_RS08280 Genome accession   NZ_LS483471
Coordinates   1578346..1580619 (+) Length   757 a.a.
NCBI ID   WP_015605555.1    Uniprot ID   A0A512ABG2
Organism   Streptococcus cristatus strain NCTC13807     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1573346..1585619
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN71_RS08250 (NCTC13807_01582) - 1573611..1574036 (+) 426 WP_015605551.1 MarR family winged helix-turn-helix transcriptional regulator -
  DQN71_RS08255 (NCTC13807_01583) - 1574158..1575699 (-) 1542 WP_015605552.1 ABC-F family ATP-binding cassette domain-containing protein -
  DQN71_RS08265 (NCTC13807_01584) - 1575954..1576610 (-) 657 WP_015605553.1 CBS domain-containing protein -
  DQN71_RS08270 (NCTC13807_01585) - 1576879..1577736 (-) 858 WP_015605554.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  DQN71_RS08275 (NCTC13807_01586) - 1577874..1578104 (-) 231 WP_002896146.1 DUF1797 family protein -
  DQN71_RS08280 (NCTC13807_01587) clpE 1578346..1580619 (+) 2274 WP_015605555.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQN71_RS08285 (NCTC13807_01588) - 1580803..1582857 (-) 2055 WP_015605556.1 cation:proton antiporter -
  DQN71_RS08290 (NCTC13807_01589) - 1582870..1583124 (-) 255 WP_015605557.1 hypothetical protein -
  DQN71_RS08295 (NCTC13807_01590) - 1583173..1583721 (-) 549 WP_015605558.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  DQN71_RS08300 (NCTC13807_01591) - 1583715..1584662 (-) 948 WP_041826825.1 TIGR01212 family radical SAM protein -
  DQN71_RS08305 (NCTC13807_01592) - 1584722..1585030 (-) 309 WP_015605560.1 MGMT family protein -

Sequence

Protein


Download         Length: 757 a.a.        Molecular weight: 84026.37 Da        Isoelectric Point: 5.0676

>NTDB_id=1142328 DQN71_RS08280 WP_015605555.1 1578346..1580619(+) (clpE) [Streptococcus cristatus strain NCTC13807]
MLCQNCKINESTIHLYTNVNGNKQQIDLCQNCYQIMKTDPNNSLFRGLAQANNQGIDPIDDFFNSLGNFQQPQEPNPNIP
PTQSGGGYGGGGYGGNSNRGSGPRQQAPQKPKGLLEEFGINVTEIARKGEIDPVIGRDEEITRVIEILNRRTKNNPVLIG
EPGVGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRSREDIILFIDEIHEIVGAG
SAGDGNMDAGNILKPALARGELQMVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTD
AAIEAAALLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKAQATRDEDFEKAAYFRDQIAKYK
ELQKTSVLDNDIPIISEKTIEHIVEQKTNIPVGDLKEKEQSQLVNLASDLKAHVIGQDDAVDKIAKAIRRNRVGLGSPNR
PIGSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYEEAGQLTERVRRNPYSLILL
DEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMN
RFDGIIEFKPLSKDNLMQIVNLMLDDVNQRLATNDIHLDVTERVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLE
NPSEKDLKAIMTSNGKILIKSAKKSETEKTKLDESKS

Nucleotide


Download         Length: 2274 bp        

>NTDB_id=1142328 DQN71_RS08280 WP_015605555.1 1578346..1580619(+) (clpE) [Streptococcus cristatus strain NCTC13807]
ATGCTTTGTCAAAATTGTAAAATCAATGAATCAACCATTCATCTCTATACAAATGTAAATGGAAATAAGCAGCAGATTGA
CCTTTGTCAAAACTGCTATCAAATCATGAAAACAGACCCTAACAATAGTCTTTTTCGAGGACTCGCTCAGGCTAACAACC
AAGGAATTGACCCTATTGATGATTTCTTTAACAGCCTTGGTAATTTCCAACAACCGCAAGAACCAAATCCAAATATCCCA
CCAACTCAATCTGGAGGAGGCTACGGTGGCGGTGGCTATGGTGGCAATTCCAACCGTGGATCTGGTCCGCGCCAACAGGC
TCCGCAAAAGCCGAAAGGTCTCCTAGAAGAGTTTGGTATCAATGTGACTGAGATTGCTCGTAAAGGAGAGATTGATCCTG
TCATCGGTCGGGACGAAGAGATTACCCGTGTCATCGAAATCCTCAACCGCCGTACCAAGAACAATCCTGTCCTTATCGGA
GAGCCTGGTGTCGGAAAAACAGCCGTGGTCGAAGGTCTAGCCCAGAAGATTGTGGATGGGGATGTGCCTCATAAACTCCA
AGGCAAGGAAGTTATCCGTCTCGACGTAGTCAGCTTGGTACAGGGGACTGGTATTCGTGGCCAATTTGAAGAGCGGATGC
AGAAGCTCATGGATGAAATTCGCTCTCGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTCGGAGCGGGC
TCAGCTGGCGATGGCAATATGGACGCTGGAAACATTCTTAAACCAGCTCTGGCTCGTGGCGAACTCCAAATGGTCGGAGC
AACTACTCTCAATGAATACCGTATCATTGAGAAAGATGCAGCCCTCGAACGTCGTATGCAGCCAGTTAAGGTGGACGAGC
CGACTGTTGAAGAAACCATTACCATTCTCAAGGGTATTCAAAAGAAATACGAAGACTACCATCACGTCAAGTACACAGAT
GCGGCTATTGAAGCAGCTGCCCTTCTCTCCAACCGCTACATCCAAGACCGCTTCCTGCCAGACAAGGCTATCGATCTCTT
GGACGAAGCAGGCTCTAAGATGAATCTGACCCTCAATTTTGTTGATCCTAAGGTCATTGACCAACGTCTGATTGAGGCCG
AAAATCTCAAGGCTCAAGCAACCCGTGACGAAGACTTTGAAAAAGCAGCTTACTTCCGCGACCAGATTGCCAAATACAAG
GAACTCCAAAAAACGAGCGTGCTGGATAACGATATTCCCATTATCAGCGAGAAAACAATTGAGCACATCGTGGAGCAAAA
GACCAATATCCCAGTTGGCGATCTCAAAGAAAAGGAACAGTCTCAACTGGTCAATCTCGCCAGCGACTTAAAAGCCCACG
TCATCGGCCAAGATGATGCCGTGGATAAGATTGCCAAAGCCATCCGCCGCAATCGGGTCGGACTAGGAAGTCCTAATCGT
CCAATCGGAAGTTTCCTCTTTGTCGGCCCAACTGGTGTCGGTAAGACTGAACTATCTAAGCAACTAGCCATTGAGCTCTT
TGGCTCGGCTGACAGCATGATTCGTTTTGACATGAGTGAATACATGGAAAAGCATAGCGTGGCCAAGCTGGTTGGTGCGC
CTCCAGGCTACGTCGGCTATGAAGAGGCTGGCCAGTTGACTGAGCGCGTCCGCCGCAATCCATACTCGCTCATTCTACTG
GATGAGGTAGAAAAGGCCCATCCTGATGTTATGCACATGTTCCTGCAGGTTTTGGATGATGGCCGCCTAACCGATGGTCA
AGGTCGGACTGTCAGCTTCAAGGACACCATTATCATTATGACATCCAATGCCGGAACGGGCAAAGCTGAAGCCAGCGTTG
GCTTTGGGGCAGCTCGTGAAGGCCGCACCAATTCCGTCTTGGGTGAATTGGGCAACTTCTTCAGCCCTGAGTTCATGAAC
CGCTTCGACGGCATCATCGAGTTTAAGCCACTCAGCAAGGACAACCTCATGCAAATCGTCAACCTCATGCTGGACGATGT
CAACCAGCGCTTGGCAACCAACGACATTCATCTGGATGTCACAGAGAGAGTCAAAGAAAAGCTGGTCGATTTAGGCTACG
ATCCCAAAATGGGGGCTCGCCCACTGCGCCGCACCATCCAGGATCATATCGAAGATGCTATTACTGACTTCTATCTGGAA
AATCCAAGCGAAAAAGATCTCAAAGCTATCATGACCAGCAATGGCAAAATTCTCATCAAGTCAGCCAAAAAATCAGAGAC
AGAAAAAACCAAGCTCGATGAAAGCAAAAGCTAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(157-276)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(651-725)

AAA domain (Cdc48 subfamily) (AAA_2)

(480-643)

AAA lid domain (AAA_lid_9)

(295-392)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A512ABG2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

87.217

99.207

0.865
  clpE Streptococcus pneumoniae D39

87.217

99.207

0.865
  clpE Streptococcus pneumoniae R6

87.217

99.207

0.865
  clpE Streptococcus pneumoniae TIGR4

87.084

99.207

0.864
  clpE Streptococcus mutans UA159

85.447

98.943

0.845
  clpC Lactococcus lactis subsp. cremoris KW2

76.556

99.736

0.764
  clpC Bacillus subtilis subsp. subtilis str. 168

51.484

89.036

0.458
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48

82.563

0.396
  clpC Streptococcus thermophilus LMD-9

47.68

82.563

0.394
  clpC Streptococcus pneumoniae Rx1

47.756

82.431

0.394
  clpC Streptococcus pneumoniae D39

47.756

82.431

0.394
  clpC Streptococcus mutans UA159

46.698

84.016

0.392
  clpC Streptococcus pneumoniae TIGR4

47.596

82.431

0.392
  clpC Streptococcus thermophilus LMG 18311

47.36

82.563

0.391

Multiple sequence alignment