Detailed information NTG1142004

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL12_RS10095
• Genome accession: NZ_LS483450
• Coordinates: 1865229..1866266 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727284.1
• Uniprot ID: A0A380LR41
• Organism: Streptococcus pneumoniae strain 4041STDY6583227
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1860229..1871266

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL12_RS10070	-	1860968..1862299 (-)	1332	WP_000390042.1	hemolysin family protein	-
DQL12_RS10075	endA	1862590..1863414 (-)	825	WP_001036783.1	DNA-entry nuclease EndA	Machinery gene
DQL12_RS10080	-	1863453..1863641 (-)	189	WP_001833890.1	DNA-directed RNA polymerase subunit beta	-
DQL12_RS10085	murA	1863634..1864917 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
DQL12_RS10090	-	1864941..1865171 (-)	231	WP_078136067.1	DUF1146 family protein	-
DQL12_RS10095	sepM	1865229..1866266 (-)	1038	WP_000727284.1	SepM family pheromone-processing serine protease	Regulator
DQL12_RS10100	coaD	1866250..1866738 (-)	489	WP_050255559.1	pantetheine-phosphate adenylyltransferase	-
DQL12_RS10105	rsmD	1866728..1867267 (-)	540	WP_000706960.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL12_RS10110	asnA	1867332..1868324 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
DQL12_RS10120	-	1868435..1869118 (-)	684	WP_001016913.1	Bax inhibitor-1 family protein	-
DQL12_RS10125	-	1869174..1869914 (-)	741	WP_000152701.1	TrmH family RNA methyltransferase	-
DQL12_RS10130	-	1869948..1870226 (+)	279	WP_001174613.1	acylphosphatase	-
DQL12_RS10135	yidC	1870304..1871230 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37551.60 Da
• Isoelectric Point: 5.0772

>NTDB_id=1142004 DQL12_RS10095 WP_000727284.1 1865229..1866266(-) (sepM) [Streptococcus pneumoniae strain 4041STDY6583227]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKEIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=1142004 DQL12_RS10095 WP_000727284.1 1865229..1866266(-) (sepM) [Streptococcus pneumoniae strain 4041STDY6583227]
ATGAAAAAAAAGATTAGATGGCCTTTGTATGTCATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTGGTGCCTTTGCC
CTACTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGAAATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A380LR41

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591