Detailed information NTG1141650

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQN35_RS03040
• Genome accession: NZ_LS483442
• Coordinates: 581144..582181 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8370
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 576144..587181

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN35_RS03015 (NCTC8370_00593)	-	576408..577739 (+)	1332	WP_011285641.1	dipeptidase	-
DQN35_RS03020 (NCTC8370_00594)	arcC	577759..578709 (+)	951	WP_010922501.1	carbamate kinase	-
DQN35_RS03025 (NCTC8370_00595)	asnA	579022..580014 (+)	993	WP_010922500.1	aspartate--ammonia ligase	-
DQN35_RS03030 (NCTC8370_00596)	rsmD	580137..580676 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQN35_RS03035 (NCTC8370_00597)	coaD	580666..581157 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQN35_RS03040 (NCTC8370_00598)	sepM	581144..582181 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQN35_RS03045 (NCTC8370_00599)	-	582595..583572 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQN35_RS03050 (NCTC8370_00600)	-	584020..584640 (+)	621	WP_011285637.1	YutD family protein	-
DQN35_RS03055 (NCTC8370_00601)	rlmN	584644..585723 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQN35_RS03060 (NCTC8370_00602)	-	585805..586431 (-)	627	WP_010922497.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1141650 DQN35_RS03040 WP_010922499.1 581144..582181(+) (sepM) [Streptococcus pyogenes strain NCTC8370]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1141650 DQN35_RS03040 WP_010922499.1 581144..582181(+) (sepM) [Streptococcus pyogenes strain NCTC8370]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693