Detailed information NTG1141340

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQN32_RS06275
• Genome accession: NZ_LS483432
• Coordinates: 1213641..1214678 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC13745
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1208641..1219678

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN32_RS06255 (NCTC13745_01246)	-	1209383..1210009 (+)	627	WP_002983834.1	prepilin peptidase	-
DQN32_RS06260 (NCTC13745_01247)	rlmN	1210091..1211170 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQN32_RS06265 (NCTC13745_01248)	-	1211174..1211794 (-)	621	WP_002992791.1	YutD family protein	-
DQN32_RS06270 (NCTC13745_01249)	-	1212242..1213219 (-)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
DQN32_RS06275 (NCTC13745_01250)	sepM	1213641..1214678 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQN32_RS06280 (NCTC13745_01251)	coaD	1214665..1215156 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQN32_RS06285 (NCTC13745_01252)	rsmD	1215146..1215685 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQN32_RS06290 (NCTC13745_01253)	asnA	1215808..1216800 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQN32_RS06295 (NCTC13745_01254)	arcC	1217113..1218063 (-)	951	WP_010922501.1	carbamate kinase	-
DQN32_RS06300 (NCTC13745_01255)	-	1218083..1219414 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1141340 DQN32_RS06275 WP_010922499.1 1213641..1214678(-) (sepM) [Streptococcus pyogenes strain NCTC13745]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1141340 DQN32_RS06275 WP_010922499.1 1213641..1214678(-) (sepM) [Streptococcus pyogenes strain NCTC13745]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693