Detailed information NTG1141274

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQN28_RS05690
• Genome accession: NZ_LS483430
• Coordinates: 1122984..1124021 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC12044
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1117984..1129021

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN28_RS05670 (NCTC12044_01131)	-	1118734..1119360 (+)	627	WP_002983834.1	prepilin peptidase	-
DQN28_RS05675 (NCTC12044_01132)	rlmN	1119442..1120521 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQN28_RS05680 (NCTC12044_01133)	-	1120525..1121145 (-)	621	WP_002992791.1	YutD family protein	-
DQN28_RS05685 (NCTC12044_01135)	-	1121593..1122570 (-)	978	WP_111686314.1	LacI family DNA-binding transcriptional regulator	-
DQN28_RS05690 (NCTC12044_01136)	sepM	1122984..1124021 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQN28_RS05695 (NCTC12044_01137)	coaD	1124008..1124499 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQN28_RS05700 (NCTC12044_01138)	rsmD	1124489..1125028 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQN28_RS05705 (NCTC12044_01139)	asnA	1125151..1126143 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQN28_RS05710 (NCTC12044_01140)	arcC	1126456..1127406 (-)	951	WP_010922501.1	carbamate kinase	-
DQN28_RS05715 (NCTC12044_01141)	-	1127426..1128757 (-)	1332	WP_002983812.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1141274 DQN28_RS05690 WP_002983824.1 1122984..1124021(-) (sepM) [Streptococcus pyogenes strain NCTC12044]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1141274 DQN28_RS05690 WP_002983824.1 1122984..1124021(-) (sepM) [Streptococcus pyogenes strain NCTC12044]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCTTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69