Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | DQN31_RS03740 | Genome accession | NZ_LS483421 |
| Coordinates | 706355..708160 (+) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NCTC10877 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 679753..726079 | 706355..708160 | within | 0 |
Gene organization within MGE regions
Location: 679753..726079
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQN31_RS03605 (NCTC10877_00710) | - | 680062..680583 (+) | 522 | WP_014407681.1 | transcription repressor NadR | - |
| DQN31_RS03610 (NCTC10877_00711) | - | 680744..681286 (+) | 543 | WP_002989140.1 | hypothetical protein | - |
| DQN31_RS03615 (NCTC10877_00712) | - | 681410..682189 (+) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
| DQN31_RS09265 | - | 682750..682941 (+) | 192 | WP_014407679.1 | hypothetical protein | - |
| DQN31_RS03625 (NCTC10877_00713) | recR | 682988..683584 (+) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| DQN31_RS03630 (NCTC10877_00714) | - | 683685..684731 (+) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| DQN31_RS03635 (NCTC10877_00715) | - | 684922..686313 (+) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| DQN31_RS03640 (NCTC10877_00716) | - | 686393..687088 (+) | 696 | WP_014407678.1 | TIGR02206 family membrane protein | - |
| DQN31_RS03650 (NCTC10877_00717) | - | 687336..688880 (+) | 1545 | WP_014407676.1 | peptide chain release factor 3 | - |
| DQN31_RS03655 (NCTC10877_00718) | - | 689187..690806 (+) | 1620 | WP_014407675.1 | DEAD/DEAH box helicase | - |
| DQN31_RS03660 (NCTC10877_00719) | - | 690934..692934 (+) | 2001 | WP_014407674.1 | potassium transporter Kup | - |
| DQN31_RS03665 (NCTC10877_00720) | - | 692958..693236 (-) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| DQN31_RS03670 (NCTC10877_00721) | - | 693226..694002 (-) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| DQN31_RS03675 (NCTC10877_00722) | - | 694120..694860 (+) | 741 | WP_041174344.1 | lysophospholipid acyltransferase family protein | - |
| DQN31_RS03680 (NCTC10877_00723) | - | 695060..695722 (+) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| DQN31_RS03685 (NCTC10877_00724) | - | 695703..697946 (+) | 2244 | WP_014407671.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| DQN31_RS03690 (NCTC10877_00725) | holA | 698017..699057 (+) | 1041 | WP_011888795.1 | DNA polymerase III subunit delta | - |
| DQN31_RS03695 (NCTC10877_00726) | sodA | 699154..699759 (+) | 606 | WP_011054658.1 | superoxide dismutase SodA | - |
| DQN31_RS03700 (NCTC10877_00727) | - | 699926..700153 (+) | 228 | WP_011054657.1 | hypothetical protein | - |
| DQN31_RS03705 (NCTC10877_00728) | - | 700138..700386 (+) | 249 | WP_011054656.1 | hypothetical protein | - |
| DQN31_RS03710 (NCTC10877_00729) | - | 700383..700973 (+) | 591 | WP_002983984.1 | serine hydrolase | - |
| DQN31_RS03715 (NCTC10877_00730) | - | 701087..702307 (-) | 1221 | WP_002983986.1 | DUF3114 domain-containing protein | - |
| DQN31_RS03720 (NCTC10877_00731) | queA | 702314..703342 (-) | 1029 | WP_002995782.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| DQN31_RS03725 (NCTC10877_00732) | nagB | 703544..704248 (+) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| DQN31_RS03730 (NCTC10877_00733) | - | 704367..705083 (+) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| DQN31_RS03735 (NCTC10877_00734) | - | 705380..706342 (+) | 963 | WP_014407670.1 | competence protein CoiA | - |
| DQN31_RS03740 (NCTC10877_00735) | pepF | 706355..708160 (+) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| DQN31_RS03745 (NCTC10877_00736) | - | 708536..709732 (+) | 1197 | WP_011054651.1 | OFA family MFS transporter | - |
| DQN31_RS03750 (NCTC10877_00737) | - | 709798..710505 (+) | 708 | WP_002989211.1 | O-methyltransferase | - |
| DQN31_RS03755 (NCTC10877_00738) | prsA | 710568..711623 (+) | 1056 | WP_014407668.1 | peptidylprolyl isomerase PrsA | - |
| DQN31_RS03760 (NCTC10877_00740) | alaS | 712010..714628 (+) | 2619 | WP_014407667.1 | alanine--tRNA ligase | - |
| DQN31_RS03765 (NCTC10877_00741) | - | 714989..715204 (+) | 216 | WP_011054648.1 | helix-turn-helix transcriptional regulator | - |
| DQN31_RS03770 (NCTC10877_00742) | - | 715201..715962 (+) | 762 | WP_014407666.1 | DUF3169 family protein | - |
| DQN31_RS03775 (NCTC10877_00743) | - | 715981..716676 (+) | 696 | WP_002984013.1 | CPBP family intramembrane glutamic endopeptidase | - |
| DQN31_RS03780 | - | 716774..717924 (-) | 1151 | Protein_665 | IS3 family transposase | - |
| DQN31_RS03785 (NCTC10877_00747) | - | 718020..719246 (-) | 1227 | WP_021775375.1 | chloride channel protein | - |
| DQN31_RS03790 (NCTC10877_00748) | nrdF | 719308..720267 (-) | 960 | WP_011017933.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| DQN31_RS03795 (NCTC10877_00749) | nrdE | 720600..722759 (-) | 2160 | WP_014407663.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| DQN31_RS03800 (NCTC10877_00750) | - | 722779..722997 (-) | 219 | WP_002989242.1 | redoxin NrdH | - |
| DQN31_RS03805 (NCTC10877_00751) | - | 723390..723653 (+) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| DQN31_RS03810 (NCTC10877_00752) | ptsP | 723658..725391 (+) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=1141057 DQN31_RS03740 WP_011054652.1 706355..708160(+) (pepF) [Streptococcus pyogenes strain NCTC10877]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1141057 DQN31_RS03740 WP_011054652.1 706355..708160(+) (pepF) [Streptococcus pyogenes strain NCTC10877]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATCATGACAGAAGC
TCTCTTAAATGAGGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATCATGACAGAAGC
TCTCTTAAATGAGGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |