Detailed information NTG1140826

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQN57_RS06050
• Genome accession: NZ_LS483415
• Coordinates: 1164517..1165554 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8304
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1159517..1170554

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN57_RS06030 (NCTC8304_01208)	-	1160271..1160897 (+)	627	WP_111705697.1	prepilin peptidase	-
DQN57_RS06035 (NCTC8304_01209)	rlmN	1160979..1162058 (-)	1080	WP_011184761.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQN57_RS06040 (NCTC8304_01210)	-	1162062..1162682 (-)	621	WP_002992791.1	YutD family protein	-
DQN57_RS06045 (NCTC8304_01211)	-	1163130..1164106 (-)	977	Protein_1122	LacI family DNA-binding transcriptional regulator	-
DQN57_RS06050 (NCTC8304_01213)	sepM	1164517..1165554 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQN57_RS06055 (NCTC8304_01214)	coaD	1165541..1166032 (-)	492	WP_111705698.1	pantetheine-phosphate adenylyltransferase	-
DQN57_RS06060 (NCTC8304_01215)	rsmD	1166022..1166561 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQN57_RS06065 (NCTC8304_01216)	asnA	1166684..1167676 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQN57_RS06070 (NCTC8304_01217)	arcC	1167989..1168939 (-)	951	WP_111705699.1	carbamate kinase	-
DQN57_RS06075 (NCTC8304_01218)	-	1168959..1170290 (-)	1332	WP_111705700.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1140826 DQN57_RS06050 WP_010922499.1 1164517..1165554(-) (sepM) [Streptococcus pyogenes strain NCTC8304]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1140826 DQN57_RS06050 WP_010922499.1 1164517..1165554(-) (sepM) [Streptococcus pyogenes strain NCTC8304]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCGGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693