Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   DQN57_RS05690 Genome accession   NZ_LS483415
Coordinates   1090197..1092002 (-) Length   601 a.a.
NCBI ID   WP_030127119.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8304     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1069931..1099816 1090197..1092002 within 0


Gene organization within MGE regions


Location: 1069931..1099816
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN57_RS05610 (NCTC8304_01121) - 1069988..1071262 (-) 1275 WP_011017930.1 polysaccharide deacetylase family protein -
  DQN57_RS05615 (NCTC8304_01122) - 1071357..1072784 (-) 1428 WP_002989248.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  DQN57_RS05620 (NCTC8304_01123) ptsP 1072969..1074702 (-) 1734 WP_111705666.1 phosphoenolpyruvate--protein phosphotransferase -
  DQN57_RS05625 (NCTC8304_01124) - 1074707..1074970 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  DQN57_RS05630 (NCTC8304_01125) nrdH 1075364..1075582 (+) 219 WP_111705667.1 glutaredoxin-like protein NrdH -
  DQN57_RS05635 (NCTC8304_01126) nrdE 1075602..1077761 (+) 2160 WP_111705668.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  DQN57_RS05640 (NCTC8304_01127) nrdF 1078094..1079053 (+) 960 WP_111705669.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  DQN57_RS05645 (NCTC8304_01128) - 1079115..1080341 (+) 1227 WP_415245014.1 chloride channel protein -
  DQN57_RS05650 - 1080437..1081587 (+) 1151 Protein_1044 IS3 family transposase -
  DQN57_RS05655 (NCTC8304_01133) - 1081684..1082379 (-) 696 WP_111705671.1 CPBP family intramembrane glutamic endopeptidase -
  DQN57_RS05660 (NCTC8304_01134) - 1082398..1083159 (-) 762 WP_053308456.1 DUF3169 family protein -
  DQN57_RS05665 (NCTC8304_01135) - 1083156..1083371 (-) 216 WP_030127117.1 helix-turn-helix transcriptional regulator -
  DQN57_RS05670 (NCTC8304_01136) alaS 1083731..1086349 (-) 2619 WP_038433280.1 alanine--tRNA ligase -
  DQN57_RS05675 (NCTC8304_01138) prsA 1086736..1087791 (-) 1056 WP_111705672.1 peptidylprolyl isomerase PrsA -
  DQN57_RS05680 (NCTC8304_01139) - 1087854..1088561 (-) 708 WP_111705673.1 O-methyltransferase -
  DQN57_RS05685 (NCTC8304_01140) - 1088627..1089823 (-) 1197 WP_038433276.1 OFA family MFS transporter -
  DQN57_RS05690 (NCTC8304_01141) pepF 1090197..1092002 (-) 1806 WP_030127119.1 oligoendopeptidase F Regulator
  DQN57_RS05695 (NCTC8304_01142) - 1092015..1092977 (-) 963 WP_111705674.1 competence protein CoiA -
  DQN57_RS05700 (NCTC8304_01143) - 1093272..1093988 (-) 717 WP_011528761.1 pseudouridine synthase -
  DQN57_RS05705 (NCTC8304_01144) nagB 1094107..1094811 (-) 705 WP_111705675.1 glucosamine-6-phosphate deaminase -
  DQN57_RS05710 (NCTC8304_01145) queA 1095013..1096041 (+) 1029 WP_111705676.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  DQN57_RS05715 (NCTC8304_01146) - 1096048..1097268 (+) 1221 WP_111705677.1 DUF3114 domain-containing protein -
  DQN57_RS05720 (NCTC8304_01147) - 1097382..1097972 (-) 591 WP_111705678.1 serine hydrolase -
  DQN57_RS05725 (NCTC8304_01148) - 1097969..1098217 (-) 249 WP_030127124.1 serine hydrolase -
  DQN57_RS05730 (NCTC8304_01149) - 1098273..1098419 (-) 147 WP_011017947.1 hypothetical protein -
  DQN57_RS05735 (NCTC8304_01150) sodA 1098586..1099191 (-) 606 WP_011017948.1 superoxide dismutase SodA -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69408.48 Da        Isoelectric Point: 4.8408

>NTDB_id=1140823 DQN57_RS05690 WP_030127119.1 1090197..1092002(-) (pepF) [Streptococcus pyogenes strain NCTC8304]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENIELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=1140823 DQN57_RS05690 WP_030127119.1 1090197..1092002(-) (pepF) [Streptococcus pyogenes strain NCTC8304]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACATTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCTCGTCAGGCTGCCATGGCTGCTAACTTTATTCCTGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCACTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTATGCAGACCGAGTGCACCGTGCCTTTACAGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGAGCTTATTCGGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTTAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Oligopeptidase F (Peptidase_M3_N)

(112-181)

Peptidase family M3 (Peptidase_M3)

(202-581)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

70.549

100

0.705

Multiple sequence alignment