Detailed information NTG1140757

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQN44_RS03035
• Genome accession: NZ_LS483414
• Coordinates: 583811..584848 (+)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC13736
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 578811..589848

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN44_RS03010 (NCTC13736_00588)	-	579075..580406 (+)	1332	WP_011054719.1	dipeptidase	-
DQN44_RS03015 (NCTC13736_00589)	arcC	580426..581376 (+)	951	WP_010922501.1	carbamate kinase	-
DQN44_RS03020 (NCTC13736_00590)	asnA	581689..582681 (+)	993	WP_111705984.1	aspartate--ammonia ligase	-
DQN44_RS03025 (NCTC13736_00591)	rsmD	582804..583343 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQN44_RS03030 (NCTC13736_00592)	coaD	583333..583824 (+)	492	WP_030127407.1	pantetheine-phosphate adenylyltransferase	-
DQN44_RS03035 (NCTC13736_00593)	sepM	583811..584848 (+)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQN44_RS03040 (NCTC13736_00595)	-	585262..586238 (+)	977	Protein_520	LacI family DNA-binding transcriptional regulator	-
DQN44_RS03045 (NCTC13736_00597)	-	586686..587306 (+)	621	WP_002992791.1	YutD family protein	-
DQN44_RS03050 (NCTC13736_00598)	rlmN	587310..588390 (+)	1081	Protein_522	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQN44_RS03055 (NCTC13736_00599)	-	588472..589098 (-)	627	WP_002989076.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1140757 DQN44_RS03035 WP_002983824.1 583811..584848(+) (sepM) [Streptococcus pyogenes strain NCTC13736]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1140757 DQN44_RS03035 WP_002983824.1 583811..584848(+) (sepM) [Streptococcus pyogenes strain NCTC13736]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGGAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGTGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69