Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   DQN33_RS06845 Genome accession   NZ_LS483408
Coordinates   1383185..1385455 (+) Length   756 a.a.
NCBI ID   WP_046393584.1    Uniprot ID   -
Organism   Streptococcus uberis strain NCTC4674     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1378185..1390455
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN33_RS06815 (NCTC4674_01455) - 1378520..1378735 (-) 216 WP_012658749.1 exodeoxyribonuclease VII small subunit -
  DQN33_RS06820 (NCTC4674_01456) xseA 1378725..1380053 (-) 1329 WP_012658750.1 exodeoxyribonuclease VII large subunit -
  DQN33_RS06825 (NCTC4674_01457) - 1380195..1381049 (-) 855 WP_111673366.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  DQN33_RS06830 (NCTC4674_01458) - 1381153..1381887 (-) 735 WP_012658752.1 amino acid ABC transporter ATP-binding protein -
  DQN33_RS06835 (NCTC4674_01459) - 1381884..1382573 (-) 690 WP_012658753.1 amino acid ABC transporter permease -
  DQN33_RS06840 (NCTC4674_01460) - 1382700..1382930 (-) 231 WP_012658754.1 DUF1797 family protein -
  DQN33_RS06845 (NCTC4674_01461) clpE 1383185..1385455 (+) 2271 WP_046393584.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQN33_RS06850 (NCTC4674_01462) - 1385589..1386044 (+) 456 WP_012658756.1 NUDIX hydrolase -
  DQN33_RS06855 (NCTC4674_01463) - 1386096..1386407 (+) 312 WP_037591782.1 DUF1827 family protein -
  DQN33_RS06860 (NCTC4674_01464) ileS 1386510..1389305 (-) 2796 WP_111673367.1 isoleucine--tRNA ligase -
  DQN33_RS06865 - 1389558..1390322 (-) 765 WP_111673368.1 DivIVA domain-containing protein -

Sequence

Protein


Download         Length: 756 a.a.        Molecular weight: 84131.36 Da        Isoelectric Point: 5.2145

>NTDB_id=1140514 DQN33_RS06845 WP_046393584.1 1383185..1385455(+) (clpE) [Streptococcus uberis strain NCTC4674]
MLCQNCKLNEATIHLYTNVNGKQRQVDLCQNCYQIMKTDTNNPILGGQNGKPQQDSINPFFDDFFGDLNNFRAFGQLPNT
PPTQSGGGQGNGGHRGGHNGSQAQAAQTQKPNGLLEEFGINVTDIARRGDIDPVIGRDDEIVRVIEILNRRTKNNPVLIG
EPGVGKTAVVEGLAQKIVDGDVPHKLQHKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRQDVILFIDEIHEIVGAG
SAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQSKYEDYHHVKYSQ
DAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLVEAENLKAQATRDEDFERAAYFRDQIAKYK
ELQKQKVDDEDTPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLSDDLKAHVIGQDDAVEKIAKAIRRNRVGLGSPNR
PIGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILL
DEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGRVEASVGFGAAREGRTNSVLGELSNYFSPEFMN
RFDGIIEFQPLSKENLLHIVDLMLEDVNARLSHNNIHLEVTAKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDFYIE
NPTEKNLKAMMSSNGNILIKAIKAKSSEEPLDMPVK

Nucleotide


Download         Length: 2271 bp        

>NTDB_id=1140514 DQN33_RS06845 WP_046393584.1 1383185..1385455(+) (clpE) [Streptococcus uberis strain NCTC4674]
ATGCTTTGTCAAAATTGTAAATTAAATGAAGCAACTATTCATCTATATACGAATGTGAATGGAAAACAAAGACAGGTAGA
TCTTTGTCAAAATTGTTATCAAATCATGAAAACAGATACTAATAATCCTATCCTAGGTGGTCAAAATGGGAAACCACAAC
AAGATTCGATAAACCCATTCTTTGATGACTTTTTTGGTGATCTCAACAATTTCAGGGCATTTGGTCAATTGCCAAACACG
CCACCGACTCAATCTGGAGGCGGACAAGGTAATGGGGGACACCGTGGAGGACACAACGGGTCACAGGCTCAAGCTGCTCA
AACGCAAAAACCAAATGGCCTTTTAGAAGAATTCGGTATCAATGTAACTGATATTGCCAGAAGAGGTGATATTGATCCTG
TTATCGGACGCGATGATGAAATTGTTCGCGTCATTGAAATTCTAAATCGACGGACTAAAAATAACCCTGTCCTTATTGGG
GAACCTGGTGTTGGTAAAACTGCAGTGGTGGAGGGTTTAGCTCAAAAAATTGTAGATGGGGATGTTCCACATAAATTACA
ACACAAACAAGTCATTCGATTAGATGTAGTCAGTTTAGTTCAAGGAACTGGCATTCGTGGTCAGTTCGAAGAACGCATGC
AAAAACTAATGGAAGAAATCCGAAATCGCCAAGATGTCATTTTATTTATTGACGAAATTCATGAGATTGTCGGTGCTGGT
AGTGCAGGCGATGGCAATATGGATGCTGGTAACATTTTAAAACCTGCCCTTGCTCGTGGAGAATTACAACTGGTTGGTGC
AACGACGTTGAATGAATATCGGATCATTGAAAAAGATGCTGCACTTGAAAGACGTATGCAGCCAGTTAAAGTTGATGAAC
CTTCAGTTGAGGAAACCATCACTATTTTAAAAGGGATTCAAAGCAAATATGAAGATTACCATCATGTGAAATACAGTCAA
GATGCTATCGAAGCTGCTGCTCACCTTTCTAATAGGTATATTCAGGATCGTTTCCTTCCCGATAAAGCCATTGATTTGCT
CGACGAAGCCGGTTCTAAAATGAACTTGACATTAAACTTTGTTGATCCCAAAGAGATTGATAAGAGATTAGTCGAAGCTG
AAAACTTAAAAGCGCAAGCCACTAGGGATGAAGATTTTGAACGCGCAGCTTACTTCAGAGACCAAATTGCAAAATACAAA
GAATTGCAAAAACAAAAGGTAGACGACGAAGACACTCCTATTATCACAGAAAAAACAATTGAAGCCATTGTTGAACAAAA
AACCAATATTCCAGTTGGCGATTTAAAGGAAAAAGAACAATCCCAATTGGTCAACTTATCAGATGATCTTAAAGCGCATG
TCATCGGTCAAGATGATGCGGTTGAAAAGATTGCAAAAGCTATTCGACGAAATCGTGTCGGACTTGGTAGCCCTAATCGT
CCTATTGGTTCTTTCCTTTTCGTTGGACCGACTGGTGTTGGTAAAACAGAGCTTTCTAAGCAATTGGCTATTGAACTTTT
TGGATCTGCTGATAATATGATTCGATTTGACATGTCGGAATACATGGAAAAACATGCTGTTGCTAAATTGGTAGGAGCGC
CTCCAGGATATGTTGGTTATGAGGAAGCTGGTCAGCTGACAGAAAAAGTTAGACGGAACCCATACTCACTTATACTTCTG
GATGAAGTTGAGAAGGCCCATCCTGATGTGATGCATATGTTCTTACAAGTTTTGGATGATGGTCGCTTAACGGATGGACA
AGGTCGAACTGTGAGCTTTAAGGACACTATTATCATCATGACTTCAAATGCGGGAACAGGACGCGTTGAAGCTTCAGTTG
GTTTTGGTGCAGCGCGTGAAGGACGTACAAACTCTGTTTTAGGCGAATTAAGTAACTACTTTAGTCCAGAATTTATGAAC
CGTTTTGATGGTATCATTGAATTCCAACCATTAAGTAAAGAAAACTTACTCCACATTGTAGATTTAATGTTGGAAGATGT
TAATGCTCGCTTATCTCATAACAATATTCATCTTGAAGTAACAGCTAAGGTTAAAGAAAAATTGGTTGATCTTGGCTATG
ACCCTAAAATGGGGGCCCGTCCTCTAAGAAGGACCATTCAAGAGCATATCGAAGATGCTATTACAGATTTCTACATAGAA
AATCCAACAGAAAAAAATCTCAAAGCTATGATGTCAAGTAATGGGAATATTCTTATTAAAGCCATTAAAGCGAAATCAAG
TGAAGAACCGCTTGATATGCCAGTTAAATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(651-726)

AAA lid domain (AAA_lid_9)

(295-392)

AAA domain (Cdc48 subfamily) (AAA_2)

(480-643)

ATPase family associated with various cellular activities (AAA) (AAA)

(157-276)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

86.577

98.545

0.853
  clpE Streptococcus pneumoniae Rx1

83.378

99.471

0.829
  clpE Streptococcus pneumoniae D39

83.378

99.471

0.829
  clpE Streptococcus pneumoniae R6

83.378

99.471

0.829
  clpE Streptococcus pneumoniae TIGR4

83.245

99.471

0.828
  clpC Lactococcus lactis subsp. cremoris KW2

77.732

96.825

0.753
  clpC Bacillus subtilis subsp. subtilis str. 168

52.516

84.127

0.442
  clpC Streptococcus pneumoniae Rx1

48.548

82.011

0.398
  clpC Streptococcus pneumoniae TIGR4

48.548

82.011

0.398
  clpC Streptococcus pneumoniae D39

48.548

82.011

0.398
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.756

82.54

0.394
  clpC Streptococcus mutans UA159

47.819

81.878

0.392
  clpC Streptococcus thermophilus LMD-9

46.624

82.275

0.384
  clpC Streptococcus thermophilus LMG 18311

46.302

82.275

0.381

Multiple sequence alignment