Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   DQM86_RS06025 Genome accession   NZ_LS483407
Coordinates   1174428..1175465 (-) Length   345 a.a.
NCBI ID   WP_111674653.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC13744     
Function   processing of CSP (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1129302..1174315 1174428..1175465 flank 113
IS/Tn 1173215..1174315 1174428..1175465 flank 113


Gene organization within MGE regions


Location: 1129302..1175465
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM86_RS05800 (NCTC13744_01155) - 1129578..1129958 (+) 381 WP_002994744.1 ImmA/IrrE family metallo-endopeptidase -
  DQM86_RS05805 (NCTC13744_01156) - 1129970..1130236 (+) 267 WP_076634078.1 DUF4177 domain-containing protein -
  DQM86_RS05810 (NCTC13744_01157) - 1130365..1131507 (+) 1143 WP_003051793.1 tyrosine-type recombinase/integrase -
  DQM86_RS05815 (NCTC13744_01158) - 1131597..1131872 (-) 276 WP_002983920.1 HU family DNA-binding protein -
  DQM86_RS05820 (NCTC13744_01159) - 1131971..1132558 (-) 588 WP_002989129.1 YpmS family protein -
  DQM86_RS05825 (NCTC13744_01160) - 1132536..1133378 (-) 843 WP_161230208.1 SGNH/GDSL hydrolase family protein -
  DQM86_RS05830 (NCTC13744_01161) - 1133371..1134210 (-) 840 WP_011054703.1 DegV family protein -
  DQM86_RS05835 (NCTC13744_01162) - 1134438..1135382 (-) 945 WP_011054704.1 LPXTG cell wall anchor domain-containing protein -
  DQM86_RS05840 (NCTC13744_01163) recN 1135554..1137215 (-) 1662 WP_085613973.1 DNA repair protein RecN -
  DQM86_RS05845 (NCTC13744_01164) - 1137237..1137707 (-) 471 WP_002983907.1 arginine repressor -
  DQM86_RS05850 (NCTC13744_01165) - 1137694..1138521 (-) 828 WP_002992345.1 TlyA family RNA methyltransferase -
  DQM86_RS05855 (NCTC13744_01166) - 1138514..1139386 (-) 873 WP_002992347.1 polyprenyl synthetase family protein -
  DQM86_RS05860 (NCTC13744_01167) - 1139386..1139601 (-) 216 WP_002983901.1 exodeoxyribonuclease VII small subunit -
  DQM86_RS05865 (NCTC13744_01168) xseA 1139579..1140919 (-) 1341 WP_111674651.1 exodeoxyribonuclease VII large subunit -
  DQM86_RS05870 (NCTC13744_01169) - 1141072..1141926 (-) 855 WP_002989114.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  DQM86_RS05875 (NCTC13744_01170) - 1142134..1143828 (-) 1695 WP_002989112.1 phospho-sugar mutase -
  DQM86_RS05880 (NCTC13744_01171) - 1144006..1145416 (-) 1411 Protein_1090 cryptochrome/photolyase family protein -
  DQM86_RS05885 (NCTC13744_01172) - 1145565..1146299 (-) 735 WP_009880900.1 amino acid ABC transporter ATP-binding protein -
  DQM86_RS05890 (NCTC13744_01173) - 1146299..1146985 (-) 687 WP_011054708.1 amino acid ABC transporter permease -
  DQM86_RS05895 (NCTC13744_01174) - 1147112..1147342 (-) 231 WP_002983885.1 YkuJ family protein -
  DQM86_RS05900 (NCTC13744_01175) clpE 1147640..1149922 (+) 2283 WP_002983882.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQM86_RS05905 (NCTC13744_01176) - 1150050..1150505 (+) 456 WP_002993341.1 NUDIX hydrolase -
  DQM86_RS05910 (NCTC13744_01177) - 1150556..1150858 (+) 303 WP_002983878.1 DUF1827 family protein -
  DQM86_RS05915 (NCTC13744_01178) ileS 1151123..1153924 (-) 2802 WP_014635582.1 isoleucine--tRNA ligase -
  DQM86_RS05920 - 1154197..1154955 (-) 759 WP_011054711.1 DivIVA domain-containing protein -
  DQM86_RS05925 (NCTC13744_01180) - 1154965..1155756 (-) 792 WP_038431452.1 RNA-binding protein -
  DQM86_RS05930 (NCTC13744_01181) - 1155756..1156010 (-) 255 WP_002983869.1 YggT family protein -
  DQM86_RS05935 (NCTC13744_01182) - 1156015..1156671 (-) 657 WP_011018004.1 cell division protein SepF -
  DQM86_RS05940 (NCTC13744_01183) - 1156683..1157354 (-) 672 WP_002989094.1 YggS family pyridoxal phosphate-dependent enzyme -
  DQM86_RS05945 (NCTC13744_01184) ftsZ 1157357..1158676 (-) 1320 WP_002983862.1 cell division protein FtsZ -
  DQM86_RS05950 (NCTC13744_01185) ftsA 1158700..1160064 (-) 1365 WP_002983860.1 cell division protein FtsA -
  DQM86_RS05955 (NCTC13744_01186) - 1160275..1161423 (-) 1149 WP_111674652.1 cell division protein FtsQ/DivIB -
  DQM86_RS05960 (NCTC13744_01187) - 1161424..1162506 (-) 1083 WP_038431456.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase -
  DQM86_RS05965 (NCTC13744_01188) murD 1162506..1163864 (-) 1359 WP_002995890.1 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase -
  DQM86_RS05970 (NCTC13744_01189) - 1164220..1164471 (-) 252 WP_002983849.1 DUF3165 family protein -
  DQM86_RS05975 (NCTC13744_01190) typA 1164593..1166434 (-) 1842 WP_002983847.1 translational GTPase TypA -
  DQM86_RS05980 (NCTC13744_01191) - 1166617..1167006 (-) 390 WP_002995894.1 rhodanese-like domain-containing protein -
  DQM86_RS05985 (NCTC13744_01192) - 1167016..1167987 (-) 972 WP_009880399.1 ROK family glucokinase -
  DQM86_RS05990 (NCTC13744_01193) - 1167992..1168195 (-) 204 WP_002983840.1 YqgQ family protein -
  DQM86_RS05995 (NCTC13744_01194) - 1168337..1168864 (-) 528 WP_014635585.1 Dps family protein -
  DQM86_RS06000 (NCTC13744_01195) - 1169092..1169718 (+) 627 WP_002989076.1 prepilin peptidase -
  DQM86_RS06005 (NCTC13744_01196) rlmN 1169800..1170879 (-) 1080 WP_002992788.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  DQM86_RS06010 (NCTC13744_01197) - 1170883..1171503 (-) 621 WP_002992791.1 YutD family protein -
  DQM86_RS06015 (NCTC13744_01199) - 1171951..1172928 (-) 978 WP_002994809.1 LacI family DNA-binding transcriptional regulator -
  DQM86_RS06020 (NCTC13744_01200) - 1173215..1174315 (-) 1101 WP_231910087.1 IS30 family transposase -
  DQM86_RS06025 (NCTC13744_01201) sepM 1174428..1175465 (-) 1038 WP_111674653.1 SepM family pheromone-processing serine protease Regulator

Sequence

Protein


Download         Length: 345 a.a.        Molecular weight: 37583.33 Da        Isoelectric Point: 9.6692

>NTDB_id=1140464 DQM86_RS06025 WP_111674653.1 1174428..1175465(-) (sepM) [Streptococcus pyogenes strain NCTC13744]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDVDFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide


Download         Length: 1038 bp        

>NTDB_id=1140464 DQM86_RS06025 WP_111674653.1 1174428..1175465(-) (sepM) [Streptococcus pyogenes strain NCTC13744]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGTTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(233-309)

PDZ domain (PDZ_2)

(129-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

68.696

100

0.687

Multiple sequence alignment