Detailed information NTG1140297

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM79_RS05995
• Genome accession: NZ_LS483401
• Coordinates: 1172931..1173968 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain NCTC10085
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1167931..1178968

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM79_RS05970 (NCTC10085_01178)	-	1167935..1168462 (-)	528	WP_002983837.1	Dps family protein	-
DQM79_RS05975 (NCTC10085_01179)	-	1168690..1169316 (+)	627	WP_002989076.1	prepilin peptidase	-
DQM79_RS05980 (NCTC10085_01180)	rlmN	1169398..1170477 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM79_RS05985 (NCTC10085_01181)	-	1170481..1171101 (-)	621	WP_032461520.1	YutD family protein	-
DQM79_RS05990 (NCTC10085_01183)	-	1171549..1172526 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
DQM79_RS05995 (NCTC10085_01184)	sepM	1172931..1173968 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
DQM79_RS06000 (NCTC10085_01185)	coaD	1173955..1174446 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM79_RS06005 (NCTC10085_01186)	rsmD	1174436..1174975 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM79_RS06010 (NCTC10085_01187)	asnA	1175098..1176090 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQM79_RS06015 (NCTC10085_01188)	arcC	1176404..1177354 (-)	951	WP_002989065.1	carbamate kinase	-
DQM79_RS06020 (NCTC10085_01189)	-	1177374..1178705 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=1140297 DQM79_RS05995 WP_002989068.1 1172931..1173968(-) (sepM) [Streptococcus pyogenes strain NCTC10085]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1140297 DQM79_RS05995 WP_002989068.1 1172931..1173968(-) (sepM) [Streptococcus pyogenes strain NCTC10085]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69