Detailed information NTG1140239

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM80_RS06130
• Genome accession: NZ_LS483399
• Coordinates: 1187870..1188907 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8227
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1182870..1193907

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM80_RS06110 (NCTC8227_01228)	-	1183621..1184247 (+)	627	WP_002989076.1	prepilin peptidase	-
DQM80_RS06115 (NCTC8227_01229)	rlmN	1184329..1185408 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM80_RS06120 (NCTC8227_01230)	-	1185412..1186032 (-)	621	WP_002992791.1	YutD family protein	-
DQM80_RS06125 (NCTC8227_01232)	-	1186480..1187457 (-)	978	WP_011054718.1	LacI family DNA-binding transcriptional regulator	-
DQM80_RS06130 (NCTC8227_01233)	sepM	1187870..1188907 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQM80_RS06135 (NCTC8227_01234)	coaD	1188894..1189385 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM80_RS06140 (NCTC8227_01235)	rsmD	1189375..1189914 (-)	540	WP_011888732.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM80_RS06145 (NCTC8227_01236)	asnA	1190037..1191029 (-)	993	WP_111702201.1	aspartate--ammonia ligase	-
DQM80_RS06150 (NCTC8227_01237)	arcC	1191342..1192292 (-)	951	WP_011528820.1	carbamate kinase	-
DQM80_RS06155 (NCTC8227_01238)	-	1192312..1193643 (-)	1332	WP_111702202.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1140239 DQM80_RS06130 WP_010922499.1 1187870..1188907(-) (sepM) [Streptococcus pyogenes strain NCTC8227]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1140239 DQM80_RS06130 WP_010922499.1 1187870..1188907(-) (sepM) [Streptococcus pyogenes strain NCTC8227]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693