Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   DQM37_RS08355 Genome accession   NZ_LS483394
Coordinates   1655355..1657805 (-) Length   816 a.a.
NCBI ID   WP_111695019.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC10880     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1650355..1662805
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM37_RS08330 (NCTC10880_01652) - 1650529..1652028 (+) 1500 WP_002991288.1 C69 family dipeptidase -
  DQM37_RS09240 - 1652352..1652693 (+) 342 Protein_1540 NUDIX domain-containing protein -
  DQM37_RS08340 (NCTC10880_01653) - 1652670..1652969 (-) 300 Protein_1541 helix-turn-helix domain-containing protein -
  DQM37_RS08345 (NCTC10880_01654) groL 1653220..1654851 (-) 1632 WP_002982320.1 chaperonin GroEL -
  DQM37_RS08350 (NCTC10880_01655) groES 1654887..1655177 (-) 291 WP_002991292.1 co-chaperone GroES -
  DQM37_RS08355 (NCTC10880_01656) clpC 1655355..1657805 (-) 2451 WP_111695019.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQM37_RS08360 (NCTC10880_01657) - 1657805..1658266 (-) 462 WP_023610213.1 CtsR family transcriptional regulator -
  DQM37_RS08365 - 1658462..1658665 (-) 204 WP_111695084.1 cold-shock protein -
  DQM37_RS08375 (NCTC10880_01660) ahpC 1659662..1660222 (+) 561 WP_002982304.1 alkyl hydroperoxide reductase subunit C -
  DQM37_RS08380 (NCTC10880_01661) ahpF 1660243..1661775 (+) 1533 WP_101248479.1 alkyl hydroperoxide reductase subunit F -

Sequence

Protein


Download         Length: 816 a.a.        Molecular weight: 90814.53 Da        Isoelectric Point: 6.9601

>NTDB_id=1140113 DQM37_RS08355 WP_111695019.1 1655355..1657805(-) (clpC) [Streptococcus pyogenes strain NCTC10880]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSEYDAQVAIEEYEAAAAAILAMGKTPKEQLSR
VDFRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDNGNGQPRLADLRKAIERHAGY
SKEMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLV
GDAGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGS
GSGIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYETYHNVSI
SNEAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPIDQALINGDMKKVSRLLAKEAKGQMRKPTP
VTEDDILATLSKLSGIPLEKLTQSDSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVG
KTELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVL
LQVLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKGIHQDHQAMEKRILEELRKTYRPEFINRIDEKVV
FHSLTQDNMRDVVKIMVQPLITTLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGH
TLKIGLSHGKLTFHIA

Nucleotide


Download         Length: 2451 bp        

>NTDB_id=1140113 DQM37_RS08355 WP_111695019.1 1655355..1657805(-) (clpC) [Streptococcus pyogenes strain NCTC10880]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCATTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGTAGATAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTGCAGCTATTTTAGCCATGGGCAAAACCCCTAAAGAACAGTTGTCTCGT
GTAGACTTCAGACCTCAATCTAAAACCTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCA
AGAAGTCGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATTATGGCGAGTCGTTTGTTAGAAATAGCTG
GCTATCAGATAAAAGATAACGGCAATGGGCAGCCGCGATTAGCTGACTTGCGAAAAGCAATAGAACGTCATGCAGGTTAC
AGTAAGGAAATGATTAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGAT
GAAGCCACCAAGTACAGCTGGTGAGTTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAAT
CGGTGATTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTACTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTG
GGTGATGCAGGTGTTGGTAAAACTGCGCTTGCTTATGGCCTTGCTCAACGGATTGCAAATGGCGCTATTCCTTATGAACT
TAAGGAGATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCA
TGAATCAAATCATTGATGATATTGAAGCTGATGGTCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGTTCT
GGCAGTGGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGCACTCTTCATATGGTTGG
AGCAACAACTCAAGAAGAATACCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTG
AAGAACCTAATACAGAAGATGCTTATCAGATTTTGATGGGCCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATA
TCAAATGAGGCAGTTAAAACAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGA
TTTATTAGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATCAGCACCTGAGACTTTAACACCAATAGACCAAG
CTCTTATCAATGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCG
GTGACAGAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAATCTGATAGTAA
AAAATACCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCA
TTCGTCGTAATCAGTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGT
AAGACAGAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGAAGCAGCGCTTATTCGTTTTGATATGTCTGAGTA
CATGGAAAAATTCGCAGCGTCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACAC
AGAAAGTTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTTCTC
CTTCAAGTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGAC
CAGCAATCTTGGCGCAACAGCCCTGCGCGATGATAAAACGGTCGGTTTTGGGGTCAAAGGCATTCACCAAGACCATCAAG
CTATGGAGAAACGTATTTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTC
TTTCATAGTCTGACCCAAGATAACATGCGCGATGTGGTTAAAATCATGGTACAGCCCCTGATTACTACATTGGCAGAAAA
AGGTATTACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAGCATATGGGGGCAAGAC
CATTACGTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATTCTTTCTCGAGAATTGACAAGTGGGCAT
ACGCTAAAAATTGGATTATCACATGGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(378-461)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(97-132)

ATPase family associated with various cellular activities (AAA) (AAA)

(238-370)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(724-803)

AAA domain (Cdc48 subfamily) (AAA_2)

(546-717)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus mutans UA159

74.847

99.877

0.748
  clpC Streptococcus thermophilus LMG 18311

71.149

100

0.713
  clpC Streptococcus thermophilus LMD-9

71.027

100

0.712
  clpC Streptococcus pneumoniae TIGR4

65.564

100

0.656
  clpC Streptococcus pneumoniae Rx1

65.564

100

0.656
  clpC Streptococcus pneumoniae D39

65.564

100

0.656
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.909

100

0.491
  clpC Bacillus subtilis subsp. subtilis str. 168

42.225

100

0.433

Multiple sequence alignment