Detailed information NTG1139995

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQN61_RS06670
• Genome accession: NZ_LS483391
• Coordinates: 1249807..1250844 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8320
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1244807..1255844

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN61_RS06650 (NCTC8320_01335)	-	1245533..1246183 (+)	651	WP_011018007.1	prepilin peptidase	-
DQN61_RS06655 (NCTC8320_01336)	rlmN	1246265..1247344 (-)	1080	WP_011018008.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQN61_RS06660 (NCTC8320_01337)	-	1247348..1247968 (-)	621	WP_002992791.1	YutD family protein	-
DQN61_RS06665 (NCTC8320_01338)	-	1248416..1249393 (-)	978	WP_072135745.1	LacI family DNA-binding transcriptional regulator	-
DQN61_RS06670 (NCTC8320_01339)	sepM	1249807..1250844 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQN61_RS06675 (NCTC8320_01340)	coaD	1250831..1251322 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQN61_RS06680 (NCTC8320_01341)	rsmD	1251312..1251851 (-)	540	WP_011018010.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQN61_RS06685 (NCTC8320_01342)	asnA	1251974..1252966 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQN61_RS06690 (NCTC8320_01343)	arcC	1253279..1254229 (-)	951	WP_011018011.1	carbamate kinase	-
DQN61_RS06695 (NCTC8320_01344)	-	1254249..1255580 (-)	1332	WP_023079479.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1139995 DQN61_RS06670 WP_010922499.1 1249807..1250844(-) (sepM) [Streptococcus pyogenes strain NCTC8320]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1139995 DQN61_RS06670 WP_010922499.1 1249807..1250844(-) (sepM) [Streptococcus pyogenes strain NCTC8320]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGCGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693