Detailed information NTG1139850

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM81_RS03050
• Genome accession: NZ_LS483389
• Coordinates: 587193..588230 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC10879
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 582193..593230

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM81_RS03025 (NCTC10879_00595)	-	582457..583788 (+)	1332	WP_111688262.1	dipeptidase	-
DQM81_RS03030 (NCTC10879_00596)	arcC	583808..584758 (+)	951	WP_010922501.1	carbamate kinase	-
DQM81_RS03035 (NCTC10879_00597)	asnA	585071..586063 (+)	993	WP_023611792.1	aspartate--ammonia ligase	-
DQM81_RS03040 (NCTC10879_00598)	rsmD	586186..586725 (+)	540	WP_038434169.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM81_RS03045 (NCTC10879_00599)	coaD	586715..587206 (+)	492	WP_014407698.1	pantetheine-phosphate adenylyltransferase	-
DQM81_RS03050 (NCTC10879_00600)	sepM	587193..588230 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQM81_RS03055 (NCTC10879_00601)	-	588654..589631 (+)	978	WP_038434168.1	LacI family DNA-binding transcriptional regulator	-
DQM81_RS03060 (NCTC10879_00602)	-	590079..590699 (+)	621	WP_038434166.1	YutD family protein	-
DQM81_RS03065 (NCTC10879_00603)	rlmN	590703..591782 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM81_RS03070 (NCTC10879_00604)	-	591864..592490 (-)	627	WP_038434165.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1139850 DQM81_RS03050 WP_010922499.1 587193..588230(+) (sepM) [Streptococcus pyogenes strain NCTC10879]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1139850 DQM81_RS03050 WP_010922499.1 587193..588230(+) (sepM) [Streptococcus pyogenes strain NCTC10879]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693