Detailed information NTG1139706

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM82_RS06720
• Genome accession: NZ_LS483386
• Coordinates: 1301442..1302479 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC13742
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1296442..1307479

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM82_RS06700 (NCTC13742_01328)	-	1297192..1297818 (+)	627	WP_010922497.1	prepilin peptidase	-
DQM82_RS06705 (NCTC13742_01329)	rlmN	1297900..1298979 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM82_RS06710 (NCTC13742_01330)	-	1298983..1299603 (-)	621	WP_002992791.1	YutD family protein	-
DQM82_RS06715 (NCTC13742_01332)	-	1300051..1301028 (-)	978	WP_023612501.1	LacI family DNA-binding transcriptional regulator	-
DQM82_RS06720 (NCTC13742_01333)	sepM	1301442..1302479 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQM82_RS06725 (NCTC13742_01334)	coaD	1302466..1302957 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM82_RS06730 (NCTC13742_01335)	rsmD	1302947..1303486 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM82_RS06735 (NCTC13742_01336)	asnA	1303609..1304601 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQM82_RS06740 (NCTC13742_01337)	arcC	1304914..1305864 (-)	951	WP_015057899.1	carbamate kinase	-
DQM82_RS06745 (NCTC13742_01338)	-	1305884..1307215 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1139706 DQM82_RS06720 WP_010922499.1 1301442..1302479(-) (sepM) [Streptococcus pyogenes strain NCTC13742]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1139706 DQM82_RS06720 WP_010922499.1 1301442..1302479(-) (sepM) [Streptococcus pyogenes strain NCTC13742]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693