Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   DQM63_RS03270 Genome accession   NZ_LS483385
Coordinates   626379..628649 (-) Length   756 a.a.
NCBI ID   WP_002902602.1    Uniprot ID   A3CLQ2
Organism   Streptococcus sanguinis strain NCTC7863     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 621379..633649
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM63_RS03235 (NCTC7863_00634) - 622775..623230 (-) 456 WP_002900910.1 MarR family winged helix-turn-helix transcriptional regulator -
  DQM63_RS03240 (NCTC7863_00635) - 623253..623687 (+) 435 WP_002902601.1 GNAT family N-acetyltransferase -
  DQM63_RS03245 (NCTC7863_00636) - 623713..624015 (-) 303 WP_002898025.1 DUF1827 family protein -
  DQM63_RS03250 (NCTC7863_00637) - 624083..624532 (-) 450 WP_002900905.1 NUDIX hydrolase -
  DQM63_RS03260 (NCTC7863_00638) - 624757..625656 (+) 900 WP_002900902.1 YafY family protein -
  DQM63_RS03265 (NCTC7863_00639) - 625716..626330 (+) 615 WP_002900899.1 GyrI-like domain-containing protein -
  DQM63_RS03270 (NCTC7863_00640) clpE 626379..628649 (-) 2271 WP_002902602.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQM63_RS03275 (NCTC7863_00641) - 628899..629129 (+) 231 WP_002896146.1 DUF1797 family protein -
  DQM63_RS03280 (NCTC7863_00642) - 629319..630173 (+) 855 WP_002902603.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  DQM63_RS03285 (NCTC7863_00643) - 630170..630943 (+) 774 WP_002902604.1 HAD hydrolase family protein -
  DQM63_RS03290 (NCTC7863_00644) - 631051..631893 (+) 843 WP_002902606.1 NAD(P)H-hydrate dehydratase -
  DQM63_RS11745 - 631869..632104 (+) 236 Protein_608 initiator RepB protein -
  DQM63_RS03300 (NCTC7863_00645) xseA 632049..633389 (+) 1341 WP_002913799.1 exodeoxyribonuclease VII large subunit -
  DQM63_RS03305 (NCTC7863_00646) - 633367..633579 (+) 213 WP_002896137.1 exodeoxyribonuclease VII small subunit -

Sequence

Protein


Download         Length: 756 a.a.        Molecular weight: 83681.75 Da        Isoelectric Point: 5.0159

>NTDB_id=1139622 DQM63_RS03270 WP_002902602.1 626379..628649(-) (clpE) [Streptococcus sanguinis strain NCTC7863]
MLCQNCKINESTIHLYTNVNGHKQQVDLCQNCYQIMKTDPEHSLFGGIANANNHGTDPIDDFFNSLSNFQQPQEPTTPPT
QSGGAYGGGGGYGSNPSKGGQPQPSPQKPKGLLEEFGINVTELARRGEIDPVIGRDEEIVRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLIDEIRSRQDVILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQMVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTDAA
IEAAALLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEL
QQTSVLDKDTPIISEKTIEHIVEQKTNIPVGDLKEKEQSQLVNLASDLKAHVIGQDDAVDKIAKAIRRNRVGLGSPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTERVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFQALSKDNLLQIVNLMLDDVNQRLATNDIHLDVTEKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLENP
SEKDLKAIMTSNGKILIKSAKKTESTESVHSSQEEK

Nucleotide


Download         Length: 2271 bp        

>NTDB_id=1139622 DQM63_RS03270 WP_002902602.1 626379..628649(-) (clpE) [Streptococcus sanguinis strain NCTC7863]
ATGCTTTGCCAAAATTGTAAAATCAACGAATCTACGATTCACCTTTATACCAACGTAAATGGCCATAAACAGCAGGTGGA
TTTGTGCCAAAACTGCTACCAAATCATGAAAACAGACCCTGAACATTCCTTGTTCGGCGGAATTGCTAATGCCAACAATC
ATGGAACAGACCCTATTGATGACTTCTTCAACAGCCTCAGCAATTTCCAACAGCCTCAGGAACCAACTACTCCTCCTACC
CAATCTGGCGGAGCCTATGGAGGCGGTGGCGGCTACGGTTCAAATCCTAGCAAGGGTGGTCAGCCTCAGCCAAGTCCGCA
AAAGCCAAAAGGCCTGCTGGAAGAGTTTGGTATCAACGTGACTGAGTTGGCTCGCCGAGGCGAGATTGATCCTGTTATTG
GCCGTGATGAAGAAATCGTCCGTGTCATTGAAATCCTCAACCGCCGCACCAAAAACAATCCTGTTCTCATAGGAGAGCCA
GGAGTCGGAAAAACAGCCGTGGTGGAAGGTCTGGCCCAGAAAATTGTCGATGGTGATGTGCCTCATAAACTCCAAGGCAA
GGAAGTTATCCGCCTAGACGTTGTCAGCTTAGTACAGGGAACTGGTATCCGTGGCCAATTTGAGGAGAGAATGCAGAAGC
TTATAGATGAGATTCGTTCTCGTCAGGATGTCATTCTCTTCATTGATGAAATCCATGAAATTGTCGGAGCAGGCTCTGCT
GGCGATGGCAATATGGACGCTGGGAACATCCTCAAACCAGCTCTGGCTCGCGGAGAACTTCAAATGGTTGGAGCAACCAC
CCTTAATGAATACCGTATCATCGAGAAGGATGCTGCGCTGGAGCGCCGCATGCAGCCGGTTAAGGTAGACGAGCCGACGG
TAGAGGAAACGATTACCATCCTCAAAGGGATTCAGAAAAAATACGAAGACTACCATCACGTCAAGTACACAGATGCAGCC
ATCGAAGCTGCTGCCCTTCTCTCCAACCGCTACATCCAAGACCGCTTCCTGCCAGACAAGGCTATTGACCTCTTGGATGA
GGCTGGATCCAAAATGAATCTGACCCTCAACTTCGTTGATCCCAAGGTCATTGACCAACGTCTGATTGAGGCCGAAAACC
TCAAGGCTCAGGCAACCCGTGACGAAGATTTCGAGAAAGCGGCTTACTTCCGTGACCAGATTGCCAAGTACAAGGAACTC
CAGCAGACAAGTGTACTAGACAAGGATACTCCGATTATCAGCGAGAAAACGATTGAGCACATCGTGGAGCAAAAGACCAA
TATCCCAGTTGGCGATCTCAAAGAAAAGGAACAGTCTCAACTAGTCAATCTCGCTAGCGACTTAAAGGCTCATGTCATCG
GCCAAGACGATGCTGTGGATAAGATTGCCAAGGCCATCCGACGCAACCGGGTCGGACTAGGAAGTCCTAATCGCCCAATC
GGCAGCTTCCTCTTTGTCGGACCTACTGGTGTCGGTAAGACTGAGCTGTCTAAGCAACTAGCCATTGAGCTATTTGGCTC
GGCTGACAGCATGATTCGCTTTGACATGAGTGAATATATGGAAAAACACAGCGTGGCCAAGCTGGTCGGTGCCCCTCCGG
GCTATGTCGGCTATGATGAAGCTGGTCAATTGACTGAGCGCGTCCGTCGTAATCCCTACTCGCTCATTCTGCTGGATGAG
GTGGAAAAGGCCCATCCTGATGTTATGCACATGTTCCTGCAGGTTCTAGATGATGGCCGCCTGACCGATGGTCAAGGCCG
GACTGTCAGCTTCAAAGACACCATTATCATCATGACATCCAATGCCGGAACTGGCAAAGCTGAAGCCAGCGTTGGCTTTG
GAGCAGCGCGTGAAGGCCGCACCAACTCCGTTTTGGGTGAATTGGGTAACTTCTTCAGTCCTGAGTTTATGAATCGCTTT
GACGGCATTATCGAATTCCAGGCGCTCAGCAAGGACAACCTGCTGCAAATCGTCAACCTTATGCTGGACGATGTTAATCA
ACGTTTGGCAACCAACGACATTCATCTGGATGTTACGGAGAAGGTCAAGGAAAAATTGGTTGACCTGGGCTACGATCCAA
AAATGGGGGCTCGCCCACTGCGCCGTACCATTCAGGACCATATCGAAGATGCTATTACTGACTTTTATCTGGAAAATCCA
AGCGAAAAAGATCTCAAAGCTATTATGACCAGCAATGGCAAGATTCTCATCAAGTCAGCCAAGAAAACTGAAAGCACAGA
GTCCGTTCATTCATCTCAAGAAGAAAAATAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)

AAA lid domain (AAA_lid_9)

(293-390)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-274)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A3CLQ2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

86.526

100

0.866
  clpE Streptococcus pneumoniae D39

86.526

100

0.866
  clpE Streptococcus pneumoniae R6

86.526

100

0.866
  clpE Streptococcus pneumoniae TIGR4

86.394

100

0.865
  clpE Streptococcus mutans UA159

83.974

99.868

0.839
  clpC Lactococcus lactis subsp. cremoris KW2

76.378

100

0.77
  clpC Bacillus subtilis subsp. subtilis str. 168

48.821

95.37

0.466
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.32

82.672

0.399
  clpC Streptococcus pneumoniae Rx1

48.631

82.143

0.399
  clpC Streptococcus pneumoniae D39

48.631

82.143

0.399
  clpC Streptococcus pneumoniae TIGR4

48.47

82.143

0.398
  clpC Streptococcus thermophilus LMD-9

47.444

82.804

0.393
  clpC Streptococcus thermophilus LMG 18311

47.125

82.804

0.39
  clpC Streptococcus mutans UA159

46.965

82.804

0.389

Multiple sequence alignment