Detailed information NTG1139571

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM87_RS03180
• Genome accession: NZ_LS483384
• Coordinates: 601152..602189 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC13743
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 596152..607189

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM87_RS03155 (NCTC13743_00621)	-	596416..597747 (+)	1332	WP_111704983.1	dipeptidase	-
DQM87_RS03160 (NCTC13743_00622)	arcC	597767..598717 (+)	951	WP_076634519.1	carbamate kinase	-
DQM87_RS03165 (NCTC13743_00623)	asnA	599030..600022 (+)	993	WP_023611792.1	aspartate--ammonia ligase	-
DQM87_RS03170 (NCTC13743_00624)	rsmD	600145..600684 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM87_RS03175 (NCTC13743_00625)	coaD	600674..601165 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM87_RS03180 (NCTC13743_00626)	sepM	601152..602189 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQM87_RS03185 (NCTC13743_00627)	-	602594..603571 (+)	978	WP_111704984.1	LacI family DNA-binding transcriptional regulator	-
DQM87_RS03190 (NCTC13743_00629)	-	604019..604639 (+)	621	WP_002992791.1	YutD family protein	-
DQM87_RS03195 (NCTC13743_00630)	rlmN	604643..605722 (+)	1080	WP_020905325.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM87_RS03200 (NCTC13743_00631)	-	605804..606430 (-)	627	WP_111704985.1	prepilin peptidase	-
DQM87_RS03205 (NCTC13743_00632)	-	606658..607185 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1139571 DQM87_RS03180 WP_010922499.1 601152..602189(+) (sepM) [Streptococcus pyogenes strain NCTC13743]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1139571 DQM87_RS03180 WP_010922499.1 601152..602189(+) (sepM) [Streptococcus pyogenes strain NCTC13743]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGTAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693