Detailed information NTG1138866

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: DQM52_RS09950
• Genome accession: NZ_LS483367
• Coordinates: 1970886..1973330 (-)
• Length: 814 a.a.
• NCBI ID: WP_111681919.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC5371
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	1968073..1979552	1970886..1973330	within	0

Gene organization within MGE regions

Location: 1968073..1979552

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM52_RS09935 (NCTC5371_02023)	-	1968073..1968540 (+)	468	WP_111681917.1	8-oxo-dGTP diphosphatase	-
DQM52_RS09940 (NCTC5371_02024)	groL	1968757..1970382 (-)	1626	WP_111681918.1	chaperonin GroEL	-
DQM52_RS09945 (NCTC5371_02025)	groES	1970418..1970708 (-)	291	WP_003054738.1	co-chaperone GroES	-
DQM52_RS09950 (NCTC5371_02026)	clpC	1970886..1973330 (-)	2445	WP_111681919.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
DQM52_RS09955 (NCTC5371_02027)	-	1973330..1973791 (-)	462	WP_003054759.1	CtsR family transcriptional regulator	-
DQM52_RS09960	-	1973987..1974190 (-)	204	WP_003053018.1	cold-shock protein	-
DQM52_RS09965 (NCTC5371_02029)	-	1974772..1975503 (+)	732	WP_231872349.1	amidohydrolase family protein	-
DQM52_RS09970 (NCTC5371_02030)	-	1975490..1976985 (-)	1496	Protein_1890	IS1182 family transposase	-
DQM52_RS09975 (NCTC5371_02031)	-	1977009..1977269 (-)	261	Protein_1891	DUF4355 domain-containing protein	-
DQM52_RS09980 (NCTC5371_02032)	-	1977407..1977631 (-)	225	WP_015058113.1	hypothetical protein	-
DQM52_RS09985 (NCTC5371_02033)	-	1977684..1978103 (-)	420	WP_015058114.1	HD domain-containing protein	-
DQM52_RS09990 (NCTC5371_02034)	-	1978100..1978306 (-)	207	WP_015058115.1	hypothetical protein	-
DQM52_RS09995 (NCTC5371_02035)	-	1978308..1979552 (-)	1245	WP_231872350.1	minor capsid protein	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90296.97 Da
• Isoelectric Point: 6.8331

>NTDB_id=1138866 DQM52_RS09950 WP_111681919.1 1970886..1973330(-) (clpC) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5371]
MIMYSLKMQEIFRQAQFQAARFDSQYLETWHILLAMARVDHSLAGLVLSEFDAKVAVEEYEAAAILAMGKSPKYQVSHID
FRPQSKTLTNLLQFAQAISQVTKDQEVGSEHVLFAILLNPDIMATRLLEMAGYTIKDKGNGEPRLADLRKAIEIHAGYSK
EIIKAIHELRKPKKTKNQGSFSDMMKPPSTAGDLADFTRDLTEMASQGLLEAVIGRDAEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQIIGDIESDGKIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNVEDAYQILLGLKGSYETYHNVTIAN
QAVRTAVKMAHRYLTSKNLPDSAIDLLDEASATVQGMVKKSRPEIITPLDQALIDGDMKKASRLLAKDVKGQHRKPTAVT
EEDILTTLSKLSGIPLEKLSQADSKKYLNLEKELHKRVIGQEDAVSAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDASALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGMLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKGISHDHQAMEKRILEELKKAYRPEFINRIDEKVVFH
SLTQDNMREVVKIMVQPLMATLAEKGITLKFQPMALKYLSEEGYDVEMGARPLRRTLQTQVEDKLSELILAGELASGHTL
KIGLSHGKLSFNLE

Nucleotide

• Length: 2445 bp

>NTDB_id=1138866 DQM52_RS09950 WP_111681919.1 1970886..1973330(-) (clpC) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5371]
ATGATCATGTATTCATTGAAGATGCAAGAAATTTTCAGGCAGGCGCAGTTTCAAGCAGCCCGCTTTGATAGCCAATACCT
AGAAACTTGGCATATATTGCTAGCTATGGCGAGGGTTGACCACTCCCTAGCGGGTTTGGTGCTAAGCGAATTTGATGCTA
AGGTTGCAGTGGAAGAATATGAGGCTGCAGCTATTTTAGCGATGGGCAAAAGTCCTAAATACCAAGTGTCTCACATTGAC
TTTAGGCCTCAGTCAAAAACCTTAACGAACCTTTTGCAATTTGCCCAAGCTATCAGTCAAGTCACCAAAGACCAAGAGGT
AGGTTCAGAGCATGTTCTCTTTGCCATTTTGCTTAATCCAGATATTATGGCTACTCGCTTATTAGAGATGGCGGGTTATA
CTATCAAGGATAAAGGAAACGGGGAGCCTCGCTTAGCTGATTTACGAAAAGCTATCGAGATTCATGCAGGCTATAGCAAG
GAAATAATTAAGGCTATCCACGAGTTGCGTAAGCCAAAGAAAACCAAAAATCAAGGTTCTTTTTCAGACATGATGAAGCC
ACCAAGCACGGCTGGGGACTTGGCGGACTTTACACGTGATTTGACCGAGATGGCAAGTCAAGGTCTCTTAGAGGCAGTTA
TTGGCCGTGATGCTGAAGTGTCACGGATGATTCAAGTACTGAGTCGTAAAACAAAGAATAACCCTGTTCTTGTGGGTGAT
GCAGGTGTGGGTAAAACGGCCCTTGCCTACGGCCTAGCCCAACGTATTGCTAATGGTGCTATTCCTTATGAGCTGCAAGA
CATGCGTGTTCTAGAATTAGACATGATGAGTGTTGTTGCGGGGACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGGCGATATTGAGTCAGATGGCAAAATTATTCTCTTCGTAGATGAATTGCACACCATTATGGGATCAGGAAGT
GGTATTGATAGCACGCTTGATGCTGCCAATATTTTAAAACCAGCCTTATCTCGTGGAACCCTCCATATGGTGGGTGCAAC
AACGCAGGAAGAATACCAAAAACACATTGAAAAAGATGCCGCTCTTTCGCGCCGCTTTGCTAAGATTTTAATTGAAGAAC
CTAATGTAGAAGATGCTTATCAGATTCTGCTAGGACTAAAAGGCTCTTACGAGACTTACCATAATGTGACCATTGCTAAT
CAGGCTGTTAGAACCGCTGTGAAAATGGCACATCGCTATCTGACCAGCAAAAACCTTCCGGATTCTGCCATTGATTTGTT
GGATGAAGCCAGTGCTACAGTGCAAGGTATGGTTAAAAAATCTAGGCCAGAAATCATCACGCCATTAGATCAAGCTTTGA
TTGATGGCGATATGAAGAAGGCCTCTCGTTTGTTGGCAAAAGACGTTAAAGGGCAACATCGCAAGCCAACAGCTGTGACA
GAAGAGGACATCCTGACGACCTTGAGCAAGCTATCAGGTATTCCACTGGAAAAACTCAGCCAAGCTGATAGCAAAAAATA
CCTTAATTTGGAAAAAGAACTGCATAAGCGCGTGATTGGGCAAGAAGATGCTGTCTCAGCTATTTCTAGAGCCATTCGCC
GTAATCAGTCAGGCATTCGTACAGGTAAACGTCCAATCGGTTCTTTCATGTTCCTTGGTCCAACAGGGGTTGGTAAGACC
GAGTTGGCAAAAGCCTTGGCAGAAGTTCTCTTTGATGACGCGTCCGCCCTTATCCGCTTTGATATGTCAGAGTATATGGA
GAAATTTGCGGCTTCTCGCCTTAATGGCGCACCTCCAGGCTATGTTGGTTACGATGAAGGTGGTGAATTAACAGAGAAGG
TCAGAAACAAGCCTTATTCTGTGCTCCTCTTTGACGAGGTGGAAAAAGCTCACCCTGATATTTTCAACGTCCTCTTACAA
GTGCTTGATGATGGCATGTTGACAGATAGCCGTGGGCGTAAAGTGGACTTCTCAAATACCATTATTATCATGACAAGTAA
TCTAGGGGCAACAGCTCTGCGTGATGATAAAACAGTTGGCTTTGGGGCAAAAGGCATTAGCCATGACCACCAAGCCATGG
AAAAACGGATTTTGGAAGAGTTGAAAAAAGCTTACCGACCAGAATTTATCAACCGAATTGATGAAAAGGTTGTCTTCCAC
AGCCTCACTCAGGACAATATGAGAGAAGTAGTCAAGATTATGGTGCAGCCGTTGATGGCTACTTTGGCAGAAAAAGGCAT
TACCCTCAAATTCCAGCCAATGGCTCTCAAGTATTTATCAGAAGAAGGGTATGATGTGGAAATGGGTGCTCGTCCATTAC
GCCGCACTTTGCAAACTCAGGTGGAAGATAAATTGTCTGAATTGATTCTTGCTGGTGAATTGGCAAGTGGTCATACCCTG
AAAATTGGCCTTTCTCATGGAAAACTCAGCTTTAACCTTGAGTGA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (15-53)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-137)

• AAA lid domain (AAA_lid_9) (376-462)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	76.384	99.877	0.763
clpC	Streptococcus thermophilus LMD-9	72.549	100	0.727
clpC	Streptococcus thermophilus LMG 18311	72.549	100	0.727
clpC	Streptococcus pneumoniae TIGR4	67.036	99.877	0.67
clpC	Streptococcus pneumoniae Rx1	67.036	99.877	0.67
clpC	Streptococcus pneumoniae D39	67.036	99.877	0.67
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.561	100	0.498
clpC	Bacillus subtilis subsp. subtilis str. 168	42.599	100	0.435