Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   DQM55_RS08375 Genome accession   NZ_LS483364
Coordinates   1691475..1693745 (+) Length   756 a.a.
NCBI ID   WP_111676150.1    Uniprot ID   A0A2X3YS40
Organism   Streptococcus sanguinis strain NCTC11086     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1686475..1698745
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM55_RS08340 (NCTC11086_01705) - 1686550..1686762 (-) 213 WP_002896137.1 exodeoxyribonuclease VII small subunit -
  DQM55_RS08345 (NCTC11086_01706) xseA 1686740..1688080 (-) 1341 WP_111676143.1 exodeoxyribonuclease VII large subunit -
  DQM55_RS11890 - 1688046..1688255 (-) 210 Protein_1571 initiator RepB protein -
  DQM55_RS08355 (NCTC11086_01707) - 1688231..1689073 (-) 843 WP_111676144.1 NAD(P)H-hydrate dehydratase -
  DQM55_RS08360 (NCTC11086_01708) - 1689181..1689954 (-) 774 WP_111676146.1 HAD hydrolase family protein -
  DQM55_RS08365 (NCTC11086_01709) - 1689951..1690805 (-) 855 WP_111676148.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  DQM55_RS08370 (NCTC11086_01710) - 1690995..1691225 (-) 231 WP_002896146.1 DUF1797 family protein -
  DQM55_RS08375 (NCTC11086_01711) clpE 1691475..1693745 (+) 2271 WP_111676150.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQM55_RS08380 (NCTC11086_01712) - 1693794..1694408 (-) 615 WP_111676152.1 GyrI-like domain-containing protein -
  DQM55_RS08385 (NCTC11086_01713) - 1694468..1695367 (-) 900 WP_111676154.1 helix-turn-helix transcriptional regulator -
  DQM55_RS08395 (NCTC11086_01714) - 1695593..1696042 (+) 450 WP_002896150.1 NUDIX hydrolase -
  DQM55_RS08400 (NCTC11086_01715) - 1696110..1696412 (+) 303 WP_002898025.1 DUF1827 family protein -
  DQM55_RS08405 (NCTC11086_01716) - 1696439..1696873 (-) 435 WP_111676156.1 GNAT family N-acetyltransferase -
  DQM55_RS08410 (NCTC11086_01717) - 1696896..1697351 (+) 456 WP_111676158.1 MarR family winged helix-turn-helix transcriptional regulator -

Sequence

Protein


Download         Length: 756 a.a.        Molecular weight: 83712.80 Da        Isoelectric Point: 4.9785

>NTDB_id=1138681 DQM55_RS08375 WP_111676150.1 1691475..1693745(+) (clpE) [Streptococcus sanguinis strain NCTC11086]
MLCQNCKINESTIHLYTNVNGHKQQVDLCQNCYQIMKTDPEHSLFGGIANTNNHGTDPIDDFFNSLSNFQQPQEPTTPPT
QSGGAYGGGGGYGSNPSKGGQPQPSPQKPKGLLEEFGINVTELARRGEIDPVIGRDEEIVRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLIDEIRSRQDVILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQMVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTDAA
IEAAALLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEL
QQTSVLDKDTPIISEKTIEHIVEQKTNIPVGDLKEKEQSQLVNLASDLKAHVIGQDDAVDKIAKAIRRNRVGLGSPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTERVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFQALSKDNLLQIVNLMLDDVNQRLATNDIHLDVTEKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDFYLENP
SEKELKAVMTSNGKILIKSAKKTESTEPVNSSQEEK

Nucleotide


Download         Length: 2271 bp        

>NTDB_id=1138681 DQM55_RS08375 WP_111676150.1 1691475..1693745(+) (clpE) [Streptococcus sanguinis strain NCTC11086]
ATGCTTTGCCAAAATTGTAAAATCAACGAATCTACGATTCACCTTTATACCAACGTAAATGGCCATAAACAGCAGGTGGA
TTTGTGCCAAAACTGCTACCAAATCATGAAAACAGACCCCGAACATTCCTTGTTCGGCGGAATTGCTAATACCAACAATC
ACGGAACAGATCCTATTGATGACTTTTTCAACAGCCTCAGCAATTTTCAACAGCCTCAGGAACCAACTACTCCTCCTACC
CAATCTGGTGGAGCCTATGGGGGCGGTGGCGGCTACGGTTCAAATCCTAGCAAGGGTGGTCAACCTCAGCCAAGTCCGCA
AAAGCCAAAAGGCCTGCTGGAAGAGTTTGGTATCAACGTGACTGAGTTGGCTCGGCGAGGCGAGATTGATCCTGTTATTG
GCCGTGATGAAGAAATCGTCCGTGTCATTGAAATCCTCAACCGCCGCACCAAAAACAATCCTGTTCTCATAGGAGAGCCC
GGAGTCGGAAAAACAGCCGTGGTGGAAGGCTTGGCCCAGAAAATTGTTGATGGTGATGTGCCTCATAAACTCCAAGGCAA
GGAAGTTATCCGCCTAGACGTTGTCAGCTTAGTACAGGGAACTGGTATCCGTGGCCAATTTGAGGAACGGATGCAGAAGC
TCATTGATGAGATTCGTTCTCGTCAGGATGTCATTCTCTTTATTGATGAAATCCATGAAATTGTCGGAGCAGGCTCTGCT
GGCGATGGCAATATGGACGCTGGGAACATCCTCAAACCAGCTCTGGCTCGCGGAGAACTCCAGATGGTCGGAGCAACCAC
CCTTAATGAATATCGTATCATCGAGAAAGATGCTGCATTGGAGCGCCGTATGCAGCCCGTTAAGGTAGACGAGCCGACGG
TAGAGGAAACGATTACCATCCTCAAAGGAATTCAGAAAAAATACGAAGACTACCATCACGTCAAGTACACGGATGCGGCT
ATTGAAGCTGCTGCCCTTCTCTCTAACCGCTACATCCAAGATCGCTTCTTGCCAGACAAGGCTATTGACCTTTTGGATGA
GGCAGGATCCAAGATGAATCTGACCCTCAACTTTGTTGATCCCAAGGTCATTGACCAACGTCTGATCGAAGCAGAAAACC
TCAAGGCTCAGGCAACTCGTGACGAAGATTTCGAGAAAGCAGCTTACTTCCGTGATCAGATTGCCAAGTACAAGGAACTC
CAGCAGACAAGTGTGCTAGACAAGGATACTCCGATTATCAGCGAGAAAACGATTGAACACATCGTAGAGCAAAAGACCAA
TATCCCAGTTGGCGATCTCAAAGAAAAGGAACAGTCTCAGCTGGTCAATCTTGCCAGCGACTTAAAGGCCCATGTCATCG
GCCAAGACGATGCTGTGGATAAGATTGCCAAGGCTATCCGCCGCAACCGAGTCGGACTAGGAAGTCCTAATCGCCCAATC
GGCAGTTTCCTCTTTGTCGGACCAACTGGTGTCGGTAAGACTGAGCTGTCTAAGCAACTAGCCATTGAGCTCTTTGGCTC
GGCTGACAGCATGATTCGCTTTGATATGAGTGAATATATGGAAAAACACAGCGTGGCCAAGCTGGTCGGTGCTCCTCCGG
GCTATGTCGGCTATGATGAAGCTGGTCAATTGACTGAGCGCGTCCGCCGTAATCCCTACTCGCTCATTCTGCTGGATGAG
GTGGAAAAGGCCCATCCTGATGTTATGCACATGTTCCTACAGGTTCTAGATGATGGCCGCCTGACTGATGGCCAAGGCCG
AACTGTCAGCTTCAAGGACACCATTATCATCATGACATCCAATGCTGGAACTGGCAAAGCTGAAGCCAGCGTTGGCTTTG
GAGCCGCGCGTGAAGGCCGCACCAATTCCGTCTTGGGTGAATTGGGCAACTTCTTCAGTCCTGAGTTTATGAACCGCTTT
GACGGGATTATCGAATTCCAGGCTCTCAGCAAGGACAATCTGCTGCAAATCGTCAACCTTATGCTGGACGATGTCAATCA
ACGTTTGGCAACCAATGACATTCATCTGGATGTTACGGAGAAGGTCAAGGAAAAATTGGTTGACCTGGGCTACGATCCAA
AAATGGGCGCTCGCCCACTGCGCCGTACCATTCAGGAACATATCGAAGATGCTATTACCGACTTCTATCTGGAAAATCCA
AGCGAAAAAGAGCTTAAAGCTGTCATGACCAGCAATGGCAAGATTCTCATCAAGTCAGCAAAGAAAACTGAAAGCACAGA
GCCCGTTAATTCATCTCAAGAAGAAAAATGA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(293-390)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-274)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-724)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X3YS40

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

86.394

100

0.865
  clpE Streptococcus pneumoniae D39

86.394

100

0.865
  clpE Streptococcus pneumoniae R6

86.394

100

0.865
  clpE Streptococcus pneumoniae TIGR4

86.262

100

0.864
  clpE Streptococcus mutans UA159

84.106

99.868

0.84
  clpC Lactococcus lactis subsp. cremoris KW2

76.76

99.603

0.765
  clpC Bacillus subtilis subsp. subtilis str. 168

48.96

95.37

0.467
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.692

85.979

0.41
  clpC Streptococcus pneumoniae Rx1

48.631

82.143

0.399
  clpC Streptococcus pneumoniae D39

48.631

82.143

0.399
  clpC Streptococcus pneumoniae TIGR4

48.47

82.143

0.398
  clpC Streptococcus thermophilus LMD-9

47.444

82.804

0.393
  clpC Streptococcus thermophilus LMG 18311

47.125

82.804

0.39
  clpC Streptococcus mutans UA159

46.965

82.804

0.389

Multiple sequence alignment