Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   DQM55_RS00935 Genome accession   NZ_LS483364
Coordinates   168826..171255 (+) Length   809 a.a.
NCBI ID   WP_111675178.1    Uniprot ID   A0A2X3YI41
Organism   Streptococcus sanguinis strain NCTC11086     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 163826..176255
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM55_RS00900 (NCTC11086_00175) nusG 163827..164363 (+) 537 WP_002894018.1 transcription termination/antitermination protein NusG -
  DQM55_RS00905 (NCTC11086_00176) - 164453..165217 (-) 765 WP_111675177.1 hypothetical protein -
  DQM55_RS00915 (NCTC11086_00178) rpsB 165724..166506 (+) 783 WP_002894015.1 30S ribosomal protein S2 -
  DQM55_RS00920 (NCTC11086_00179) tsf 166579..167622 (+) 1044 WP_002894014.1 translation elongation factor Ts -
  DQM55_RS00925 (NCTC11086_00180) - 167726..168214 (-) 489 WP_172454690.1 hypothetical protein -
  DQM55_RS00930 (NCTC11086_00181) - 168361..168825 (+) 465 WP_002899234.1 CtsR family transcriptional regulator -
  DQM55_RS00935 (NCTC11086_00182) clpC 168826..171255 (+) 2430 WP_111675178.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQM55_RS00940 - 171349..172093 (+) 745 Protein_160 DUF4272 domain-containing protein -
  DQM55_RS00945 (NCTC11086_00185) - 172136..172621 (+) 486 WP_172454691.1 ECF transporter S component -
  DQM55_RS00950 (NCTC11086_00186) - 172605..173006 (+) 402 WP_111675180.1 DUF4430 domain-containing protein -
  DQM55_RS00955 (NCTC11086_00187) - 173192..174250 (+) 1059 WP_111675181.1 AAA family ATPase -
  DQM55_RS00960 (NCTC11086_00188) pnuC 174272..175087 (+) 816 WP_111675182.1 nicotinamide riboside transporter PnuC -
  DQM55_RS00965 (NCTC11086_00189) - 175142..175930 (+) 789 WP_111675183.1 NUDIX domain-containing protein -

Sequence

Protein


Download         Length: 809 a.a.        Molecular weight: 89644.16 Da        Isoelectric Point: 5.1953

>NTDB_id=1138645 DQM55_RS00935 WP_111675178.1 168826..171255(+) (clpC) [Streptococcus sanguinis strain NCTC11086]
MKYSKALIESLEAAQLLAGHFTTDYLESWHLLIALANNPYSVAGSVLNEFPVEVDGFEEAAFQITGQAYQKDGHFELLPF
SYRLEELFEEAGQIAEAVRAKHVGTEHVLLAMLFDRGTLASRILEFTGFSYEDKEQGPKISDLRKILEQRAGWGKEDIKA
IRSLNKGVMAAKQTMANMMGMPASTSGGLEDYTRDLTELARDGRLEPVIGRDQEISRIVQILSRKTKNNPVLVGDAGVGK
TALALGLAQRVAAGQVPAELAKMRVLELDLMNVVAGTRFRGDFEERMNNIINDIEEDGHVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVSIEEPNVADSIAILQGLRKSYEDHHKVQISDQAIET
AVKYAHRYLTSKHLPDSAIDLLDEASATVQNRGPQNYEQSDLTPVDQALMAADFKKVSQLLEQEQQPKLYKLKVEEDDVL
ATLSGLSGIPVQKLTQTDAKKYLNLETELHKRVIGQDEAISAISRAIRRNQSGIRSSKRPIGSFMFLGPTGVGKTELAKA
LAESLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNRPYSVLLFDEVEKAHPDIFNVLLQVLDDG
QLTDSKGRKVDFSNTIIIMTSNLGATSLRDDKTVGFGARDIRLDHANMEKRMLEELKKAYRPEFINRIDEKVVFHSLSAE
DMQEVVKVMVKPLIASLAEKGIELKFQASALKLLAQEGYDVEMGARPLRRTLQTQVEDKLSELLLTGDLTTGQTLKVGVK
AGQLKFEVS

Nucleotide


Download         Length: 2430 bp        

>NTDB_id=1138645 DQM55_RS00935 WP_111675178.1 168826..171255(+) (clpC) [Streptococcus sanguinis strain NCTC11086]
ATGAAATACTCAAAAGCCTTAATAGAAAGCTTGGAAGCAGCCCAGCTCTTGGCCGGCCATTTTACGACAGATTATCTGGA
ATCATGGCATCTGCTGATTGCTCTAGCTAATAATCCCTACAGCGTTGCTGGTTCAGTCCTCAATGAGTTTCCTGTGGAAG
TTGATGGATTTGAAGAAGCAGCTTTTCAGATTACTGGTCAGGCTTATCAGAAAGACGGTCACTTCGAGCTGCTGCCTTTT
TCTTATCGCTTAGAGGAGTTGTTTGAGGAGGCGGGCCAGATTGCAGAAGCTGTTCGCGCTAAGCATGTAGGTACTGAGCA
TGTGCTGCTGGCCATGCTATTTGACAGAGGAACCTTGGCCTCTCGTATTCTGGAATTTACCGGCTTTAGCTACGAGGACA
AGGAGCAAGGACCGAAAATCAGTGATTTGCGAAAGATCTTGGAGCAGCGAGCTGGCTGGGGCAAGGAAGATATCAAGGCT
ATTCGCAGTCTGAATAAGGGAGTAATGGCAGCTAAGCAGACCATGGCTAATATGATGGGTATGCCAGCTTCTACCAGCGG
GGGGCTAGAAGACTACACTCGTGATCTGACGGAGCTGGCTAGAGATGGCCGATTGGAGCCCGTCATTGGCCGTGATCAGG
AAATTTCACGGATAGTTCAGATTCTTAGTCGCAAGACTAAAAATAATCCAGTGCTGGTTGGAGATGCTGGGGTTGGTAAG
ACGGCTCTGGCCTTAGGATTGGCCCAACGTGTAGCGGCCGGTCAGGTTCCTGCTGAACTTGCCAAGATGCGGGTTTTGGA
GCTGGACTTGATGAATGTAGTCGCTGGCACTCGCTTTCGCGGAGATTTCGAGGAGCGGATGAACAACATCATCAATGACA
TTGAAGAAGATGGTCATGTCATTCTCTTCATCGATGAGCTGCATACCATCATGGGCTCTGGCAGCGGTATTGACTCGACC
TTGGATGCGGCCAATATCCTGAAACCGGCTCTGGCTCGCGGCACTCTGCGGACAGTTGGCGCCACGACGCAGGAAGAGTA
TCAGAAACATATTGAAAAAGATGCGGCTCTTTCCCGGCGTTTTGCCAAGGTCAGCATAGAAGAGCCAAATGTGGCTGACA
GCATTGCTATTTTACAAGGTCTGAGAAAGAGCTATGAGGACCATCATAAGGTACAGATTAGTGATCAGGCTATTGAGACG
GCGGTGAAATACGCCCATCGCTATCTGACTAGCAAGCATCTGCCTGACTCTGCTATTGATCTTTTAGATGAGGCTAGTGC
GACAGTCCAGAACAGAGGACCGCAGAATTACGAGCAGTCGGATTTGACGCCAGTGGATCAAGCCTTGATGGCAGCGGATT
TTAAAAAGGTTTCACAACTGCTTGAGCAAGAGCAGCAACCTAAGCTCTATAAACTGAAAGTGGAAGAAGACGATGTTTTG
GCTACTCTGAGTGGCTTGTCTGGTATTCCAGTGCAGAAGCTGACTCAGACAGATGCGAAGAAATACCTCAATTTGGAAAC
AGAACTGCATAAACGCGTGATTGGGCAGGACGAGGCGATTTCAGCTATCAGCCGAGCTATCCGACGGAACCAGTCTGGTA
TCCGCAGTAGCAAGCGGCCGATCGGATCTTTTATGTTCCTAGGTCCGACAGGAGTCGGGAAGACAGAGCTAGCCAAAGCT
TTGGCCGAAAGTCTCTTTGATGACGAATCTGCTCTCATCCGCTTTGATATGAGTGAGTACATGGAGAAATTCGCGGCTAG
CCGCCTCAACGGAGCGCCTCCAGGCTATGTAGGCTATGAAGAAGGAGGGGAGTTGACGGAGAAGGTACGCAACCGACCTT
ATTCTGTCCTGCTCTTTGACGAGGTGGAAAAGGCGCACCCGGATATTTTCAATGTTCTCCTGCAGGTCTTGGATGATGGT
CAGTTGACTGACAGCAAGGGCCGCAAGGTGGACTTCTCCAACACGATTATTATCATGACCAGCAATCTGGGGGCAACTAG
TTTGCGGGATGATAAGACGGTGGGCTTTGGAGCGCGGGATATTCGCTTGGACCATGCCAATATGGAAAAACGGATGCTGG
AAGAGCTTAAGAAAGCTTATCGACCAGAGTTTATCAACCGTATCGACGAAAAGGTAGTTTTCCACAGCTTATCTGCAGAA
GATATGCAGGAAGTGGTCAAGGTTATGGTCAAACCGCTCATTGCCAGTCTTGCTGAGAAGGGAATTGAGCTGAAGTTCCA
GGCTAGTGCCCTTAAGCTGCTGGCTCAGGAAGGCTACGATGTGGAAATGGGGGCACGGCCATTGCGCCGCACTCTGCAGA
CTCAGGTGGAGGACAAGCTGTCTGAGCTACTCTTGACAGGAGATTTGACAACGGGTCAAACTCTTAAGGTCGGAGTCAAA
GCTGGCCAACTCAAGTTCGAAGTGTCCTAG

Domains

Predicted by InterproScan.

Clp amino terminal domain, pathogenicity island component (Clp_N)

(14-60)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(100-133)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(717-797)

AAA lid domain (AAA_lid_9)

(371-463)

ATPase family associated with various cellular activities (AAA) (AAA)

(231-362)

AAA domain (Cdc48 subfamily) (AAA_2)

(539-710)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X3YI41

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae Rx1

77.654

100

0.777
  clpC Streptococcus pneumoniae D39

77.654

100

0.777
  clpC Streptococcus pneumoniae TIGR4

77.654

100

0.777
  clpC Streptococcus mutans UA159

67.813

100

0.682
  clpC Streptococcus thermophilus LMG 18311

66.79

100

0.671
  clpC Streptococcus thermophilus LMD-9

66.667

100

0.67
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

50.605

100

0.517
  clpC Bacillus subtilis subsp. subtilis str. 168

45.443

99.011

0.45
  clpE Streptococcus mutans UA159

47.65

76.267

0.363

Multiple sequence alignment