Detailed information NTG1138422

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL29_RS05930
• Genome accession: NZ_LS483359
• Coordinates: 1172493..1173530 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC12068
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1167493..1178530

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL29_RS05910 (NCTC12068_01173)	-	1168242..1168868 (+)	627	WP_030126387.1	prepilin peptidase	-
DQL29_RS05915 (NCTC12068_01174)	rlmN	1168950..1170029 (-)	1080	WP_030126386.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL29_RS05920 (NCTC12068_01175)	-	1170033..1170653 (-)	621	WP_002992791.1	YutD family protein	-
DQL29_RS05925 (NCTC12068_01177)	-	1171101..1172078 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQL29_RS05930 (NCTC12068_01178)	sepM	1172493..1173530 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQL29_RS05935 (NCTC12068_01179)	coaD	1173517..1174008 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL29_RS05940 (NCTC12068_01180)	rsmD	1173998..1174537 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL29_RS05945 (NCTC12068_01181)	asnA	1174660..1175652 (-)	993	WP_023611792.1	aspartate--ammonia ligase	-
DQL29_RS05950 (NCTC12068_01182)	arcC	1175965..1176915 (-)	951	WP_010922501.1	carbamate kinase	-
DQL29_RS05955 (NCTC12068_01183)	-	1176935..1178266 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1138422 DQL29_RS05930 WP_002983824.1 1172493..1173530(-) (sepM) [Streptococcus pyogenes strain NCTC12068]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1138422 DQL29_RS05930 WP_002983824.1 1172493..1173530(-) (sepM) [Streptococcus pyogenes strain NCTC12068]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGCAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69