Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | DQL29_RS05570 | Genome accession | NZ_LS483359 |
| Coordinates | 1098184..1099989 (-) | Length | 601 a.a. |
| NCBI ID | WP_030126417.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NCTC12068 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1077923..1124984 | 1098184..1099989 | within | 0 |
Gene organization within MGE regions
Location: 1077923..1124984
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQL29_RS05490 (NCTC12068_01089) | - | 1077961..1079235 (-) | 1275 | WP_002989251.1 | polysaccharide deacetylase family protein | - |
| DQL29_RS05495 (NCTC12068_01090) | - | 1079330..1080757 (-) | 1428 | WP_030126519.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| DQL29_RS05500 (NCTC12068_01091) | ptsP | 1080924..1082657 (-) | 1734 | WP_030126520.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| DQL29_RS05505 (NCTC12068_01092) | - | 1082662..1082925 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| DQL29_RS05510 (NCTC12068_01093) | nrdH | 1083318..1083536 (+) | 219 | WP_030126521.1 | glutaredoxin-like protein NrdH | - |
| DQL29_RS05515 (NCTC12068_01094) | nrdE | 1083556..1085715 (+) | 2160 | WP_111717960.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| DQL29_RS05520 (NCTC12068_01095) | nrdF | 1086048..1087007 (+) | 960 | WP_030126523.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| DQL29_RS05525 (NCTC12068_01096) | - | 1087069..1088295 (+) | 1227 | WP_409233904.1 | chloride channel protein | - |
| DQL29_RS05530 (NCTC12068_01098) | - | 1088434..1089577 (+) | 1144 | Protein_1017 | IS3 family transposase | - |
| DQL29_RS05535 (NCTC12068_01099) | - | 1089669..1090364 (-) | 696 | WP_111689540.1 | CPBP family intramembrane glutamic endopeptidase | - |
| DQL29_RS05540 (NCTC12068_01100) | - | 1090383..1091144 (-) | 762 | WP_053308456.1 | DUF3169 family protein | - |
| DQL29_RS05545 (NCTC12068_01101) | - | 1091141..1091356 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| DQL29_RS05550 (NCTC12068_01102) | alaS | 1091717..1094335 (-) | 2619 | WP_011284933.1 | alanine--tRNA ligase | - |
| DQL29_RS05555 (NCTC12068_01104) | prsA | 1094722..1095777 (-) | 1056 | WP_111717964.1 | peptidylprolyl isomerase PrsA | - |
| DQL29_RS05560 (NCTC12068_01105) | - | 1095840..1096547 (-) | 708 | WP_002989211.1 | O-methyltransferase | - |
| DQL29_RS05565 (NCTC12068_01106) | - | 1096613..1097809 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| DQL29_RS05570 (NCTC12068_01107) | pepF | 1098184..1099989 (-) | 1806 | WP_030126417.1 | oligoendopeptidase F | Regulator |
| DQL29_RS05575 (NCTC12068_01108) | - | 1100002..1100964 (-) | 963 | WP_002983995.1 | competence protein CoiA | - |
| DQL29_RS05580 (NCTC12068_01109) | - | 1101259..1101975 (-) | 717 | WP_030126416.1 | pseudouridine synthase | - |
| DQL29_RS05585 (NCTC12068_01110) | nagB | 1102049..1102798 (-) | 750 | WP_030126415.1 | glucosamine-6-phosphate deaminase | - |
| DQL29_RS05590 (NCTC12068_01111) | queA | 1103000..1104028 (+) | 1029 | WP_011284937.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| DQL29_RS05595 (NCTC12068_01112) | - | 1104035..1105255 (+) | 1221 | WP_030126414.1 | DUF3114 domain-containing protein | - |
| DQL29_RS05600 (NCTC12068_01113) | - | 1105369..1105959 (-) | 591 | WP_011528765.1 | serine hydrolase | - |
| DQL29_RS05605 (NCTC12068_01114) | - | 1105956..1106204 (-) | 249 | WP_010922432.1 | serine hydrolase | - |
| DQL29_RS05610 (NCTC12068_01115) | - | 1106189..1106416 (-) | 228 | WP_030126413.1 | hypothetical protein | - |
| DQL29_RS05615 (NCTC12068_01116) | sodA | 1106583..1107188 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| DQL29_RS05620 (NCTC12068_01117) | holA | 1107285..1108325 (-) | 1041 | WP_030126412.1 | DNA polymerase III subunit delta | - |
| DQL29_RS05625 (NCTC12068_01118) | - | 1108396..1110639 (-) | 2244 | WP_111717966.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| DQL29_RS05630 (NCTC12068_01119) | - | 1110620..1111282 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| DQL29_RS05635 (NCTC12068_01120) | - | 1111482..1112222 (-) | 741 | WP_012560804.1 | lysophospholipid acyltransferase family protein | - |
| DQL29_RS05640 (NCTC12068_01121) | - | 1112340..1113116 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| DQL29_RS05645 (NCTC12068_01122) | - | 1113106..1113384 (+) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| DQL29_RS05650 (NCTC12068_01123) | - | 1113408..1115408 (-) | 2001 | WP_030126409.1 | potassium transporter Kup | - |
| DQL29_RS05655 (NCTC12068_01124) | - | 1115536..1117155 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| DQL29_RS05660 (NCTC12068_01125) | - | 1117462..1119006 (-) | 1545 | WP_002989155.1 | peptide chain release factor 3 | - |
| DQL29_RS05670 (NCTC12068_01126) | - | 1119254..1119949 (-) | 696 | WP_030126408.1 | TIGR02206 family membrane protein | - |
| DQL29_RS05675 (NCTC12068_01127) | - | 1120029..1121420 (-) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| DQL29_RS05680 (NCTC12068_01128) | - | 1121611..1122657 (-) | 1047 | WP_030126407.1 | D-alanine--D-alanine ligase | - |
| DQL29_RS05685 (NCTC12068_01129) | recR | 1122758..1123354 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| DQL29_RS09020 | - | 1123401..1123592 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| DQL29_RS05695 (NCTC12068_01130) | - | 1124153..1124932 (-) | 780 | WP_111717968.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69395.39 Da Isoelectric Point: 4.7743
>NTDB_id=1138419 DQL29_RS05570 WP_030126417.1 1098184..1099989(-) (pepF) [Streptococcus pyogenes strain NCTC12068]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADEIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADEIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1138419 DQL29_RS05570 WP_030126417.1 1098184..1099989(-) (pepF) [Streptococcus pyogenes strain NCTC12068]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATGAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATGAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
70.549 |
100 |
0.705 |