Detailed information NTG1138351

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: DQM46_RS09135
• Genome accession: NZ_LS483357
• Coordinates: 1767983..1770427 (-)
• Length: 814 a.a.
• NCBI ID: WP_111678905.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8326
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1762983..1775427

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM46_RS09110 (NCTC8326_01818)	-	1763246..1764745 (+)	1500	WP_021299123.1	C69 family dipeptidase	-
DQM46_RS10000	-	1765038..1765284 (+)	247	Protein_1691	8-oxo-dGTP diphosphatase	-
DQM46_RS09120 (NCTC8326_01819)	-	1765270..1765597 (-)	328	Protein_1692	helix-turn-helix domain-containing protein	-
DQM46_RS09125 (NCTC8326_01820)	groL	1765848..1767479 (-)	1632	WP_002982320.1	chaperonin GroEL	-
DQM46_RS09130 (NCTC8326_01821)	groES	1767515..1767805 (-)	291	WP_002991292.1	co-chaperone GroES	-
DQM46_RS09135 (NCTC8326_01822)	clpC	1767983..1770427 (-)	2445	WP_111678905.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
DQM46_RS09140 (NCTC8326_01823)	-	1770427..1770888 (-)	462	WP_002982312.1	CtsR family transcriptional regulator	-
DQM46_RS09145	-	1771084..1771287 (-)	204	WP_002991299.1	cold-shock protein	-
DQM46_RS09155 (NCTC8326_01826)	ahpC	1772272..1772832 (+)	561	WP_011529076.1	alkyl hydroperoxide reductase subunit C	-
DQM46_RS09160 (NCTC8326_01827)	ahpF	1772853..1774385 (+)	1533	WP_011529077.1	alkyl hydroperoxide reductase subunit F	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90741.52 Da
• Isoelectric Point: 6.9602

>NTDB_id=1138351 DQM46_RS09135 WP_111678905.1 1767983..1770427(-) (clpC) [Streptococcus pyogenes strain NCTC8326]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSEYDAQVAIEEYEAAAILAMGKTPKEQLSRVD
FRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDSGNGQPRLADLRKAIERHAGYSK
EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYETYHNVSISN
EAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKLAPETLTPIDQALINGDMKKVSRLLAKEAKGQMRKPTPVT
EDDILATLSKLSGIPLEKLTQADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKDIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFH
SLTQDNMRDVVKIMVRPLITTLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSHGKLTFHIA

Nucleotide

• Length: 2445 bp

>NTDB_id=1138351 DQM46_RS09135 WP_111678905.1 1767983..1770427(-) (clpC) [Streptococcus pyogenes strain NCTC8326]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCACTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGTAGACAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTATTTTAGCCATGGGCAAAACCCCTAAGGAACAGTTGTCTCGTGTAGAC
TTCAGACCTCAATCTAAAACTTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCAAGAAGT
CGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATTATGGCGAGTCGCTTGTTAGAAATAGCAGGCTATC
AGATAAAAGATAGCGGCAATGGGCAGCCGCGATTAGCTGACTTACGAAAAGCAATAGAACGTCATGCAGGTTACAGTAAG
GAAATGATCAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGATGAAGCC
ACCAAGTACAGCTGGTGAGTTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAATCGGTGA
TTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTATTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTAGGTGAT
GCAGGTGTTGGTAAAACGGCGCTTGCTTATGGCCTTGCTCAACGGATTGCAAATGGCGCTATTCCTTATGAACTTAAGGA
GATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGATGATATTGAAGCTGATGGTCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGTTCTGGCAGT
GGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGCACTCTTCATATGGTTGGAGCAAC
AACTCAAGAAGAATATCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTGAAGAAC
CTAATACAGAAGATGCTTATCAGATTTTGATGGGCCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATATCAAAT
GAAGCAGTTAAAACAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGATTTATT
AGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATTAGCACCTGAGACTTTAACACCAATAGACCAAGCTCTTA
TCAATGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCAGTGACA
GAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAAGCTGATAGTAAAAAATA
CCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCATTCGTC
GCAATCAGTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGTAAGACA
GAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGAAGCAGCGCTTATTCGTTTTGATATGTCTGAGTACATGGA
AAAATTCGCAGCGTCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACACAGAAAG
TTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTTCTCCTTCAA
GTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGACCAGCAA
TCTTGGCGCAACAGCCCTGCGCGATGATAAAACGGTCGGTTTTGGGGTCAAAGACATTCACCAAGACCATCAAGCTATGG
AGAAACGTATTTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTCTTTCAT
AGTCTGACCCAAGATAACATGCGCGATGTGGTTAAAATCATGGTACGGCCCCTGATTACTACATTGGCAGAAAAAGGTAT
TACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAGCATATGGGGGCAAGACCATTAC
GTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATCCTTTCTCGAGAATTGACAAGTGGGCATACGCTA
AAAATTGGATTATCACATGGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

• AAA lid domain (AAA_lid_9) (376-457)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-130)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	75.154	99.877	0.751
clpC	Streptococcus thermophilus LMG 18311	71.324	100	0.715
clpC	Streptococcus thermophilus LMD-9	71.201	100	0.714
clpC	Streptococcus pneumoniae TIGR4	65.971	100	0.66
clpC	Streptococcus pneumoniae Rx1	65.971	100	0.66
clpC	Streptococcus pneumoniae D39	65.971	100	0.66
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.852	100	0.493
clpC	Bacillus subtilis subsp. subtilis str. 168	42.326	100	0.434