Detailed information NTG1138327

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM46_RS03045
• Genome accession: NZ_LS483357
• Coordinates: 580995..582032 (+)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC8326
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 575995..587032

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM46_RS03020 (NCTC8326_00593)	-	576259..577590 (+)	1332	WP_011054719.1	dipeptidase	-
DQM46_RS03025 (NCTC8326_00594)	arcC	577610..578560 (+)	951	WP_011528820.1	carbamate kinase	-
DQM46_RS03030 (NCTC8326_00595)	asnA	578873..579865 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQM46_RS03035 (NCTC8326_00596)	rsmD	579988..580527 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM46_RS03040 (NCTC8326_00597)	coaD	580517..581008 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM46_RS03045 (NCTC8326_00598)	sepM	580995..582032 (+)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQM46_RS03050 (NCTC8326_00599)	-	582446..583423 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQM46_RS03055 (NCTC8326_00601)	-	583871..584491 (+)	621	WP_002992791.1	YutD family protein	-
DQM46_RS03060 (NCTC8326_00602)	rlmN	584495..585574 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM46_RS03065	-	585656..586283 (-)	628	Protein_520	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1138327 DQM46_RS03045 WP_002983824.1 580995..582032(+) (sepM) [Streptococcus pyogenes strain NCTC8326]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1138327 DQM46_RS03045 WP_002983824.1 580995..582032(+) (sepM) [Streptococcus pyogenes strain NCTC8326]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69