Detailed information NTG1138284

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM51_RS06915
• Genome accession: NZ_LS483356
• Coordinates: 1295473..1296510 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC8230
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1290473..1301510

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM51_RS06895 (NCTC8230_01376)	-	1291223..1291849 (+)	627	WP_002983834.1	prepilin peptidase	-
DQM51_RS06900 (NCTC8230_01377)	rlmN	1291931..1293010 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM51_RS06905 (NCTC8230_01378)	-	1293014..1293634 (-)	621	WP_002992791.1	YutD family protein	-
DQM51_RS06910 (NCTC8230_01380)	-	1294082..1295059 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQM51_RS06915 (NCTC8230_01381)	sepM	1295473..1296510 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQM51_RS06920 (NCTC8230_01382)	coaD	1296497..1296988 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM51_RS06925 (NCTC8230_01383)	rsmD	1296978..1297517 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM51_RS06930 (NCTC8230_01384)	asnA	1297640..1298632 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQM51_RS06935 (NCTC8230_01385)	arcC	1298945..1299895 (-)	951	WP_010922501.1	carbamate kinase	-
DQM51_RS06940 (NCTC8230_01386)	-	1299915..1301246 (-)	1332	WP_002983812.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1138284 DQM51_RS06915 WP_002983824.1 1295473..1296510(-) (sepM) [Streptococcus pyogenes strain NCTC8230]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1138284 DQM51_RS06915 WP_002983824.1 1295473..1296510(-) (sepM) [Streptococcus pyogenes strain NCTC8230]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69