Detailed information NTG1138228

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL02_RS05720
• Genome accession: NZ_LS483355
• Coordinates: 1127959..1128996 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC12067
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1122959..1133996

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL02_RS05700 (NCTC12067_01139)	-	1123701..1124327 (+)	627	WP_002983834.1	prepilin peptidase	-
DQL02_RS05705 (NCTC12067_01140)	rlmN	1124409..1125488 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL02_RS05710 (NCTC12067_01141)	-	1125492..1126112 (-)	621	WP_002992791.1	YutD family protein	-
DQL02_RS05715 (NCTC12067_01142)	-	1126560..1127537 (-)	978	WP_063510263.1	LacI family DNA-binding transcriptional regulator	-
DQL02_RS05720 (NCTC12067_01143)	sepM	1127959..1128996 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL02_RS05725 (NCTC12067_01144)	coaD	1128983..1129474 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL02_RS05730 (NCTC12067_01145)	rsmD	1129464..1130003 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL02_RS05735 (NCTC12067_01146)	asnA	1130126..1131118 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQL02_RS05740 (NCTC12067_01147)	arcC	1131431..1132381 (-)	951	WP_010922501.1	carbamate kinase	-
DQL02_RS05745 (NCTC12067_01148)	-	1132401..1133732 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1138228 DQL02_RS05720 WP_010922499.1 1127959..1128996(-) (sepM) [Streptococcus pyogenes strain NCTC12067]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1138228 DQL02_RS05720 WP_010922499.1 1127959..1128996(-) (sepM) [Streptococcus pyogenes strain NCTC12067]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693