Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | DQL02_RS05360 | Genome accession | NZ_LS483355 |
| Coordinates | 1053602..1055407 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NCTC12067 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1033372..1080401 | 1053602..1055407 | within | 0 |
Gene organization within MGE regions
Location: 1033372..1080401
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQL02_RS05280 (NCTC12067_01054) | - | 1033410..1034684 (-) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
| DQL02_RS05285 (NCTC12067_01055) | - | 1034779..1036206 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| DQL02_RS05290 (NCTC12067_01056) | ptsP | 1036391..1038124 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| DQL02_RS05295 (NCTC12067_01057) | - | 1038129..1038392 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| DQL02_RS05300 (NCTC12067_01058) | - | 1038785..1039003 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| DQL02_RS05305 (NCTC12067_01059) | nrdE | 1039023..1041182 (+) | 2160 | WP_031488773.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| DQL02_RS05310 (NCTC12067_01060) | nrdF | 1041515..1042474 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| DQL02_RS05315 (NCTC12067_01061) | - | 1042536..1043762 (+) | 1227 | WP_021340858.1 | chloride channel protein | - |
| DQL02_RS05320 | - | 1043858..1045015 (+) | 1158 | Protein_979 | IS3 family transposase | - |
| DQL02_RS05325 (NCTC12067_01065) | - | 1045107..1045802 (-) | 696 | WP_063510258.1 | CPBP family intramembrane glutamic endopeptidase | - |
| DQL02_RS05330 (NCTC12067_01066) | - | 1045821..1046582 (-) | 762 | WP_031488552.1 | DUF3169 family protein | - |
| DQL02_RS05335 (NCTC12067_01067) | - | 1046579..1046794 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| DQL02_RS05340 (NCTC12067_01069) | alaS | 1047134..1049752 (-) | 2619 | WP_031488551.1 | alanine--tRNA ligase | - |
| DQL02_RS05345 (NCTC12067_01071) | prsA | 1050139..1051194 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| DQL02_RS05350 (NCTC12067_01072) | - | 1051257..1051964 (-) | 708 | WP_002984000.1 | O-methyltransferase | - |
| DQL02_RS05355 (NCTC12067_01073) | - | 1052030..1053226 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| DQL02_RS05360 (NCTC12067_01074) | pepF | 1053602..1055407 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| DQL02_RS05365 (NCTC12067_01075) | - | 1055420..1056382 (-) | 963 | WP_053039058.1 | competence protein CoiA | - |
| DQL02_RS05370 (NCTC12067_01076) | - | 1056678..1057394 (-) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| DQL02_RS05375 (NCTC12067_01077) | nagB | 1057513..1058217 (-) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| DQL02_RS05380 (NCTC12067_01078) | queA | 1058419..1059447 (+) | 1029 | WP_031488549.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| DQL02_RS05385 (NCTC12067_01079) | - | 1059454..1060674 (+) | 1221 | WP_002983986.1 | DUF3114 domain-containing protein | - |
| DQL02_RS05390 (NCTC12067_01080) | - | 1060788..1061378 (-) | 591 | WP_002983984.1 | serine hydrolase | - |
| DQL02_RS09040 | - | 1061375..1061602 (-) | 228 | WP_226316535.1 | hypothetical protein | - |
| DQL02_RS05400 (NCTC12067_01081) | - | 1061603..1061836 (-) | 234 | WP_002983979.1 | hypothetical protein | - |
| DQL02_RS05405 (NCTC12067_01082) | sodA | 1062003..1062608 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| DQL02_RS05410 (NCTC12067_01083) | holA | 1062705..1063745 (-) | 1041 | WP_031488548.1 | DNA polymerase III subunit delta | - |
| DQL02_RS05415 (NCTC12067_01084) | - | 1063816..1066059 (-) | 2244 | WP_031488547.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| DQL02_RS05420 (NCTC12067_01085) | - | 1066040..1066702 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| DQL02_RS05425 (NCTC12067_01086) | - | 1066902..1067642 (-) | 741 | WP_031488546.1 | lysophospholipid acyltransferase family protein | - |
| DQL02_RS05430 (NCTC12067_01087) | - | 1067760..1068536 (+) | 777 | WP_111703075.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| DQL02_RS05435 (NCTC12067_01088) | - | 1068526..1068804 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| DQL02_RS05440 (NCTC12067_01089) | - | 1068828..1070828 (-) | 2001 | WP_053039059.1 | potassium transporter Kup | - |
| DQL02_RS05445 (NCTC12067_01090) | - | 1070955..1072574 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| DQL02_RS05450 (NCTC12067_01091) | - | 1072881..1074425 (-) | 1545 | WP_031488544.1 | peptide chain release factor 3 | - |
| DQL02_RS05460 (NCTC12067_01092) | - | 1074673..1075368 (-) | 696 | WP_031488543.1 | TIGR02206 family membrane protein | - |
| DQL02_RS05465 (NCTC12067_01093) | - | 1075448..1076839 (-) | 1392 | WP_031488542.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| DQL02_RS05470 (NCTC12067_01094) | - | 1077030..1078076 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| DQL02_RS05475 (NCTC12067_01095) | recR | 1078177..1078773 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| DQL02_RS09155 | - | 1078820..1079011 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| DQL02_RS05485 (NCTC12067_01096) | - | 1079570..1080349 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=1138225 DQL02_RS05360 WP_011054652.1 1053602..1055407(-) (pepF) [Streptococcus pyogenes strain NCTC12067]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1138225 DQL02_RS05360 WP_011054652.1 1053602..1055407(-) (pepF) [Streptococcus pyogenes strain NCTC12067]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |