Detailed information NTG1138086

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL39_RS02035
• Genome accession: NZ_LS483353
• Coordinates: 388525..389562 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC4001
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 383525..394562

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL39_RS02010 (NCTC4001_00393)	-	383789..385120 (+)	1332	WP_011888730.1	dipeptidase	-
DQL39_RS02015 (NCTC4001_00394)	arcC	385140..386090 (+)	951	WP_011528820.1	carbamate kinase	-
DQL39_RS02020 (NCTC4001_00395)	asnA	386403..387395 (+)	993	WP_011888731.1	aspartate--ammonia ligase	-
DQL39_RS02025 (NCTC4001_00396)	rsmD	387518..388057 (+)	540	WP_011888732.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL39_RS02030 (NCTC4001_00397)	coaD	388047..388538 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL39_RS02035 (NCTC4001_00398)	sepM	388525..389562 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL39_RS02040 (NCTC4001_00399)	-	389974..390951 (+)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
DQL39_RS02045 (NCTC4001_00400)	-	391399..392019 (+)	621	WP_002992791.1	YutD family protein	-
DQL39_RS02050 (NCTC4001_00401)	rlmN	392023..393102 (+)	1080	WP_011184761.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL39_RS02055 (NCTC4001_00402)	-	393184..393810 (-)	627	WP_002989076.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1138086 DQL39_RS02035 WP_010922499.1 388525..389562(+) (sepM) [Streptococcus pyogenes strain NCTC4001]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1138086 DQL39_RS02035 WP_010922499.1 388525..389562(+) (sepM) [Streptococcus pyogenes strain NCTC4001]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693