Detailed information NTG1138058

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL37_RS06645
• Genome accession: NZ_LS483352
• Coordinates: 1256698..1257735 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC12052
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1251698..1262735

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL37_RS06620 (NCTC12052_01322)	-	1251702..1252229 (-)	528	WP_002983837.1	Dps family protein	-
DQL37_RS06625 (NCTC12052_01323)	-	1252457..1253083 (+)	627	WP_002983834.1	prepilin peptidase	-
DQL37_RS06630 (NCTC12052_01324)	rlmN	1253165..1254244 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL37_RS06635 (NCTC12052_01325)	-	1254248..1254868 (-)	621	WP_002992791.1	YutD family protein	-
DQL37_RS06640 (NCTC12052_01326)	-	1255316..1256293 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQL37_RS06645 (NCTC12052_01327)	sepM	1256698..1257735 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL37_RS06650 (NCTC12052_01328)	coaD	1257722..1258213 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL37_RS06655 (NCTC12052_01329)	rsmD	1258203..1258742 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL37_RS06660 (NCTC12052_01330)	asnA	1258865..1259857 (-)	993	WP_002994813.1	aspartate--ammonia ligase	-
DQL37_RS06665 (NCTC12052_01331)	arcC	1260170..1261120 (-)	951	WP_111685793.1	carbamate kinase	-
DQL37_RS06670 (NCTC12052_01332)	-	1261140..1262471 (-)	1332	WP_109828595.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1138058 DQL37_RS06645 WP_010922499.1 1256698..1257735(-) (sepM) [Streptococcus pyogenes strain NCTC12052]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1138058 DQL37_RS06645 WP_010922499.1 1256698..1257735(-) (sepM) [Streptococcus pyogenes strain NCTC12052]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693