Detailed information NTG1138000

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM42_RS06830
• Genome accession: NZ_LS483351
• Coordinates: 1270498..1271535 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC8195
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1265498..1276535

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM42_RS06810 (NCTC8195_01371)	-	1266248..1266874 (+)	627	WP_002983834.1	prepilin peptidase	-
DQM42_RS06815 (NCTC8195_01372)	rlmN	1266956..1268035 (-)	1080	WP_002983832.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM42_RS06820 (NCTC8195_01373)	-	1268039..1268659 (-)	621	WP_032467263.1	YutD family protein	-
DQM42_RS06825 (NCTC8195_01375)	-	1269107..1270084 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQM42_RS06830 (NCTC8195_01376)	sepM	1270498..1271535 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQM42_RS06835 (NCTC8195_01377)	coaD	1271522..1272013 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM42_RS06840 (NCTC8195_01378)	rsmD	1272003..1272542 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM42_RS06845 (NCTC8195_01379)	asnA	1272665..1273657 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQM42_RS06850 (NCTC8195_01380)	arcC	1273970..1274920 (-)	951	WP_002983814.1	carbamate kinase	-
DQM42_RS06855 (NCTC8195_01381)	-	1274940..1276271 (-)	1332	WP_002983812.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1138000 DQM42_RS06830 WP_002983824.1 1270498..1271535(-) (sepM) [Streptococcus pyogenes strain NCTC8195]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1138000 DQM42_RS06830 WP_002983824.1 1270498..1271535(-) (sepM) [Streptococcus pyogenes strain NCTC8195]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69